Dose: Intravenous or Subcutaneous Injection – 50-100 units/kg
Frequency: three times weekly initially
Note: Initiate only when (1) hemoglobin level less than 10 g/dL, (2) rate of hemoglobin decline indicates likely necessity of red blood cell transfusion, and (3) reducing risk of alloimmunization or other risks related to red blood cell transfusion is goal; if hemoglobin level greater than 10 g/dL, reduce or interrupt dose and use lowest dose sufficient to reduce need for red blood cell transfusion