Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adults |
Dose: 250 mg Frequency: every 6 hours Note: May increase up to 4 g/day, according to severity of infection. Hepatic Impairment: Use caution |
|
Age: Adults |
Dose: 500 mg Frequency: every 12 hours Note: May increase up to 4 g/day, according to severity of infection. Hepatic Impairment: Use caution |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Children |
Dose: by mouth (oral) – 50 mg/kg/day Frequency: every 6 to 8 hours |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Dose adjustment not necessary |
Administration
- Take on empty stomach
- Take 30 minutes to 2 hours before meals
Side Effect
- Abdominal pain (8%)
- Headache (8%)
- Nausea (8%)
- Diarrhea (7%)
- Rash (3%)
- Vomiting (3%)
- Dyspepsia (2%)
- Flatulence (2%)
- Pain (2%)
- Pruritus (1%)
- Pseudomembranous colitis
- Hypertrophic pyloric stenosis
- Anaphylaxis
- Fever
- Mild allergic reactions
- Urticaria
- Skin eruptions
- Tinnitus
- Cholestatic hepatitis
- Confusion
- Hallucinations
- Hearing loss
- Hypotension
- Nervous system effects including seizures
- Torsade de pointes
- Ventricular tachycardia
- Vertigo
- Hepatotoxicity
- cholestatic jaundice
- raised serum transaminases
- eosinophilia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Valproic acid
|
May decrease plasma levels, increasing risk of seizures
|
|
Probenecid
|
Increased plasma concentrations
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Porphyria
|
Can trigger acute attacks
|
|
Hepatic Impairment
|
Can worsen liver function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.