Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Susceptible infections Age: Adult |
Dose: Oral – 200 mg on day 1 followed by 100 mg Frequency: once daily Note: Day 1 can be given as a single or in divided doses. |
|
Indication: Severe infections Age: Adult |
Dose: Oral – 200 mg Frequency: once daily Note: Maintain initial dose throughout the course of treatment. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Children |
Dose: by mouth (oral) – 2–4 mg/kg/day Frequency: every 12 hours |
Administration
- Take with or without food
- Take with full glass of water
Side Effect
- Hypotension
- pericarditis
- angioneurotic oedema
- dyspnoea
- serum sickness
- peripheral oedema
- tachycardia
- urticaria
- haemolytic anaemia
- thrombocytopenia
- neutropenia
- porphyria
- eosinophilia
- brown-black microscopic discolouration of thyroid tissue
- headache
- bulging fontanelles in infants and benign intracranial HTN in adults
- blurring of vision
- scotomata
- diplopia
- tinnitus
- abdominal pain
- stomatitis
- anorexia
- nausea
- vomiting
- diarrhoea
- dyspepsia
- oesophageal ulceration
- discolouration of teeth
- enamel hypoplasia
- transient increases in LFT and BUN
- jaundice
- pancreatitis
- rashes
- exfoliative dermatitis
- photo-onycholysis
- photosensitivity
- arthralgia
- myalgia
- vaginitis
- Anaphylactoid reactions
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- Clostridium difficile-associated disease (CDAD)
- hepatotoxicity
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Isotretinoin
|
May cause pseudotumour cerebri
|
|
Warfarin
|
Prolonged prothrombin time
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Hepatic Disorder
|
Can worsen liver function
|
|
Systemic Lupus Erythematosus
|
Can exacerbate SLE symptoms
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.