Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oral Treatment and prophylaxis of venous thromboembolism, Stroke and Thromboembolism, Post-Myocardial Infarction Age: Adult |
Dose: Oral – Initially, 2-5 mg Frequency: once daily Duration: for 2 days Note: Alternatively, 10 mg daily for 2 days in healthy individuals. Initiate warfarin on day 1 or 2 of low molecular weight heparin or unfractionated heparin therapy and overlap until desired International Normalized Ratio, then discontinue heparin. Check International Normalized Ratio after 2 days and adjust dose according to results. |
|
Indication: Oral Treatment and prophylaxis of venous thromboembolism, Stroke and Thromboembolism, Post-Myocardial Infarction Age: Adult |
Dose: Oral – 2-10 mg Frequency: once daily Note: Usual maintenance dose. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Thrombosis Prevention/treatment Condition: baseline INR 1.0-1.3 |
Dose: Oral dose – 0.1-0.2 mg/kg Frequency: once daily Duration: 1 day Note: by mouth (oral); check INR on days 2-4 and adjust daily dose to maintain INR between 2.0 and 3.0 (unless valve replacement indicates a higher range) |
|
Indication: Thrombosis Prevention/treatment Condition: liver impairment |
Dose: Oral dose – 0.1 mg/kg Note: by mouth (oral); used to initiate therapy |
Administration
- Can be taken with or without food
- Take at same time each day
Side Effect
- oral anticoagulants
- Jaundice
- hepatic dysfunction
- vasculitis
- pancreatitis
- nausea
- vomiting
- diarrhoea
- taste perversion
- abdominal pain
- flatulence
- bloating
- rash
- purpura
- erythematous swollen skin patches leading to ecchymosis
- pruritus
- alopecia
- purple discolouration of toes due to cholesterol embolisation
- tracheal or tracheobronchial calcification
- fever
- chills
- Unexplained drop in haematocrit
- decreased Hb
- Rarely
- hypersensitivity reactions
- Haemorrhage from almost any organ of the body w/ the consequent effects of haematomas as well as anaemia
- tissue necrosis and/or gangrene of skin or other tissues w/ SC infarction
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Ticlopidine
|
Cholestatic hepatitis may occur
|
|
Other Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban) (e.g. argatroban, dabigatran, heparin), antiplatelet agents (e.g. aspirin, cilostazol, clopidogrel), NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac) (e.g. celecoxib, diclofenac, ibuprofen), serotonin reuptake inhibitors (e.g. citalopram, paroxetine, venlafaxine)
|
Increased risk of bleeding
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Haemorrhagic Tendencies, Blood Dyscrasias
|
High risk of severe bleeding
|
|
Recent CNS or Eye Surgery
|
Risk of surgical site bleeding
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.