Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertriglyceridemia, Hypercholesterolemia |
Dose: by mouth – 600 mg Frequency: every 12 hours |
|
Condition: Hepatic impairment |
Dose: by mouth Note: Contraindicated |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Mild to moderate renal impairment |
Dose: Dose: Note: Use caution if baseline serum creatinine in patient is greater than 2 milligrams per deciliter; deterioration of renal function reported in such patients |
|
Condition: Severe renal impairment |
Dose: Dose: Note: Contraindicated |
Administration
- Take 30min before meals
- Take twice daily
Side Effect
- Dyspepsia (20%)
- Abdominal pain (10%)
- Atrial fibrillation (1%)
- Diarrhea (7%)
- Fatigue (4%)
- N/V (3%)
- Eczema (2%)
- Rash (2%)
- Vertigo (2%)
- Constipation (1%)
- Headache (1%)
- Myalgia
- Rhabdomyolysis (especially with administration with statin)
- Acute appendicitis
- Cholelithiasis
- Angioedema
- Hypokalemia
- Eosinophilia
- Myopathy
- Synovitis
- Taste disturbance
- Xerostomia
- Flatulence
- Rash
- Bone marrow hypoplasia
- intracranial haemorrhage
- nephrotoxicity
- peripheral neuritis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Repaglinide
|
May increase serum levels of repaglinide
|
|
Oral Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May enhance effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Hepatic Dysfunction
|
Can worsen liver function
|
|
Severe Renal Dysfunction
|
Can cause drug accumulation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.