Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oropharyngeal Candidiasis |
Dose: Oral – 200 mg Frequency: once daily on Day 1 Note: Followed by 100 mg once daily. Treatment should be continued for at least 2 weeks to decrease likelihood of relapse |
|
Indication: Oropharyngeal Candidiasis |
Dose: Oral – 100 mg Frequency: once daily Note: Treatment should be continued for at least 2 weeks to decrease likelihood of relapse |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: by mouth (oral) – 3–12 mg/kg/day Frequency: every 24 hours Note: maximum 600 mg/day |
|
Age: Child Condition: central nervous system fungal infections |
Dose: by mouth (oral) – 800–1,000 mg/day Note: used for some central nervous system fungal infections |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Haemodialysis patients |
Dose: Dosage – Usual dose Frequency: Given after each session |
|
Age: Adult Condition: Renal impairment with Creatinine Clearance less than 50 ml/min and not receiving dialysis |
Dose: Dosage – 50% of the usual dose Note: For patients with Creatinine Clearance less than 50 ml/min and not receiving dialysis |
Administration
- Take with or without food
- Take with full glass of water
Side Effect
- Headache (2-13%)
- Nausea (2-7%)
- Abdominal pain (2-6%)
- Diarrhea (2-3%)
- Rash (2%)
- Vomiting (2-5%)
- QT prolongation
- Torsades de pointes
- Alopecia
- Anaphylactic reactions
- Angioedema
- Cholestasis
- Dizziness
- Dyspnea
- Hepatic failure
- Hepatitis
- Hypertriglyceridemia
- Hypokalemia
- Increased alkaline phosphatase
- Increased ALT/AST
- Jaundice
- Leukopenia
- Pallor
- Seizures
- Stevens-Johnson syndrome
- Taste perversion
- Thrombocytopenia
- Toxic epidermal necrolysis
- Hepatotoxicity
- rarely anaphylaxis
- Stevens-Johnson syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Oral hypoglycaemics (e.g. tolbutamide, glyburide, glipizide), Phenytoin, Theophylline, Tofacitinib, Rifabutin
|
May increase plasma concentrations
|
|
Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban)
|
May increase prothrombin time
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.