Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Tuberculosis Age: Adult |
Dose: Oral – 10 mg/kg/day or 2-3 times/week Note: Maximum: 600 mg/day |
|
Indication: Tuberculosis Age: Adult |
Dose: Oral – 450 mg Frequency: daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Tuberculosis |
Dose: Oral – 10–20 mg/kg Frequency: once every 24 hours Note: max 600 mg for TB |
|
Indication: Tuberculosis Condition: With directly observed biweekly therapy |
Dose: Oral – 10–20 mg/kg/dose Frequency: twice weekly Note: max 600 mg |
Administration
- Take on empty stomach
- Take 1 hour before or 2 hours after meals
Side Effect
- Facial flushing and itching
- w/ or w/o a rash
- flu-like syndrome characterised by episodes of fever
- chills
- headache
- dizziness
- bone pain
- shortness of breath
- and malaise
- GI adverse effects (eg nausea, vomiting, anorexia, diarrhoea, epigastric distress)
- pseudomembranous colitis
- eosinophilia
- leucopenia
- haemolytic anaemia
- alterations in kidney function and renal failure
- menstrual disturbances
- oedema
- myopathy
- muscular weakness
- orange-red discolouration of the urine
- faeces
- sweat
- saliva
- sputum
- tears
- and other body fluids
- Rarely
- eye irritation and visual disturbances
- anaphylaxis or shock
- Hepatotoxicity
- hypotension
- sinus tachycardia
- ventricular arrhythmias
- seizures and cardiac arrest
- thrombocytopenia and purpura
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Quinidine, Phenytoin, Theophylline
|
May accelerate metabolism and reduce effect
|
|
Atovaquone
|
Decreased concentrations of atovaquone and increased concentrations of rifampicin
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity
|
Severe allergic reactions possible
|
|
Jaundice
|
Can worsen liver condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30° C. Avoid excessive heat and protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.