Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: Adult |
Dose: Oral – Initially, 2.5-5 mg Frequency: daily Note: May increase weekly by increments of 2.5-15 mg daily. Doses greater than 10 mg daily should be given in 2 divided doses. Maximum: 20 mg daily. |
|
Indication: Type 2 diabetes mellitus Age: Elderly |
Dose: Oral – Initially, 1.25 mg Frequency: daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Severe renal impairment |
Dose: Not specified Note: Contraindicated in severe renal impairment |
Administration
- Take with breakfast
- Regular timing daily
Side Effect
- Hypoglycaemia
- cholestatic jaundice
- agranulocytosis
- aplastic anaemia
- haemolytic anaemia
- Blood dyscrasias (reversible)
- liver dysfunction
- GI symptoms
- allergic skin reactions
- Prolonged hypoglycaemia seen in elderly or debilitated patients with hepatic or renal diseases
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Colesevelam
|
Serum levels may be reduced
|
|
MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide), Chloramphenicol, Fluoroquinolones (e.g. ciprofloxacin), Probenecid, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Fluoxetine, Disopyramide, Clarithromycin, Salicylates, Sulfonamides, Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol)
|
May increase hypoglycaemic effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Or Life-Threatening Hyperglycaemia
|
Can worsen blood sugar control
|
|
Severe Liver Or Renal Failure
|
Can cause drug accumulation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Should be stored in a dry place below 30˚ C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.