Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: Adult Condition: Conventional preparation |
Dose: Oral preparation – 500 mg Frequency: twice daily or three times daily Note: Initially 500 mg twice daily or three times daily, or 850 mg 1-2 times daily, may increase gradually to 2000 mg daily at intervals of at least 1 week. Maximum daily dose of 2550 mg per day. |
|
Indication: Type 2 diabetes mellitus Age: Adult Condition: Modified-release preparation |
Dose: Oral preparation – 500 mg Frequency: once daily Note: Initially 500 mg once daily, may increase in increments of 500 mg at intervals of at least 1 week to maximum 2000 mg once daily at night. If glycaemic control is not sufficient, dose may be divided to 1000 mg twice daily. Not to exceed 2000 mg/day. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: greater than 10 yr |
Dose: Oral – 500 mg Frequency: 1-2 times daily Note: initially, may increase gradually to maximum 2000 mg daily in 2 or 3 divided doses at intervals of at least 1 week |
|
Indication: Type 2 diabetes mellitus Age: greater than 10 yr |
Dose: Oral – 850 mg Frequency: once daily Note: initially, may increase gradually to maximum 2000 mg daily in 2 or 3 divided doses at intervals of at least 1 week |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Elderly Condition: Renal impairment |
Dose: Tablet – Dosage not specified Note: Monitor estimated glomerular filtration rate at least annually or more often for those at risk for renal impairment |
|
Condition: Renal impairment with estimated glomerular filtration rate less than 30 mL/min/1.73 m2 |
Dose: Tablet – Dosage not specified Note: Contraindicated; discontinue the drug if estimated glomerular filtration rate falls below 30 mL/min/1.73 m2 while taking metformin |
Administration
- Take with food
- Take with meals to reduce stomach upset
Side Effect
- Anorexia
- nausea
- vomiting
- diarrhoea
- weight loss
- flatulence
- occasional metallic taste
- weakness
- hypoglycaemia
- rash
- malabsorption of vit B12
- Chest discomfort
- flushing
- palpitation
- chills
- headache
- lightheadedness
- indigestion
- abdominal discomfort
- Lactic acidosis in presence of renal failure and alcoholism
- Patients may experience a metallic taste and there may be weight loss
- which in some diabetics could be an advantage
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Sulfonylureas
|
Additive effect
|
|
Thiazide diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone), Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone), Phenothiazines, Oral contraceptives, Sympathomimetics (Ephedrine, Pseudoephedrine, Phenylephrine), Niacin, Calcium Channel Blockers (Amlodipine, Diltiazem, Verapamil, Nifedipine, Felodipine, Nicardipine, Isradipine), Isoniazid
|
May exacerbate loss of glycaemic control
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute/Chronic Metabolic Acidosis
|
Can worsen acid-base balance
|
|
Diabetic Ketoacidosis
|
Increases risk of severe acidosis
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.