Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Rheumatoid arthritis Age: Adult |
Dose: Oral – 250-500 mg Frequency: up to 3 times daily Duration: 3-7 days Note: Maximum 1.5 gm total |
|
Indication: Mild to moderate pain Age: Adult |
Dose: Oral – 250-500 mg Frequency: up to 3 times daily Duration: 3-7 days Note: Maximum 1.5 gm total |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Rheumatoid arthritis Age: Child: greater than 6 months |
Dose: Oral – 25 mg/kg Frequency: daily in divided doses Duration: up to 7 days |
|
Indication: Mild to moderate pain Age: Child: greater than 6 months |
Dose: Oral – 25 mg/kg Frequency: daily in divided doses Duration: up to 7 days |
Administration
- Take with food
- Regular timing
Side Effect
- Borderline elevations of one or more LFTs (Less than 15%)
- Abdominal pain
- Anorexia
- Diarrhea
- Nausea
- Pyrosis
- Gastritis
- Flatulence
- Constipation
- Steatorrhea
- Upper GI ulcers
- gross bleeding/perforation (1% of patients treated for 3-6 mth and 2-4% of those treated for 1 year old)
- Leukopenia
- Eosinophilia
- Thrombocytopenic purpura
- Agranulocytosis
- Pancytopenia
- Bone marrow hypoplasia
- Renal failure (including papillary necrosis & acute interstitial nephritis)
- Acute interstitial nephritis has been associated with hematuria
- proteinuria
- & nephrotic syndrome
- Autoimmune haemolytic anaemia
- convulsions (overdosage)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP2C9 isoenzyme inhibitors
|
May alter safety and efficacy
|
|
Methotrexate
|
May enhance toxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity to NSAIDs
|
Risk of severe allergic reaction
|
|
Inflammatory bowel disease
|
Can worsen inflammation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep away from light, store in a cool and dry place. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.