Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Inflammatory/Rheumatoid Disorders Age: Adult Condition: Immediate release |
Dose: Oral – 25-50 mg Frequency: every 8-12 hours Note: not to exceed 200 mg/day |
|
Indication: Inflammatory/Rheumatoid Disorders Age: Adult Condition: Extended release |
Dose: Oral – 75-150 mg/day Frequency: in single daily dose or divided every 12 hours Note: not to exceed 150 mg/day |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Inflammatory/Rheumatoid Disorders Age: less than 2 years |
Dose: Oral – Not established Note: Safety and efficacy not established |
|
Indication: Inflammatory/Rheumatoid Disorders Age: 2-14 years |
Dose: Oral – 1-2 mg/kg/day Frequency: divided every 6-12 hours Note: not to exceed 4 mg/kg/day or 150-200 mg/day |
Administration
- Take with food
- Regular timing
Side Effect
- Transient renal insufficiency (40%)
- Jaundice (Less than 15%)
- Elevated liver function test values (≤15%)
- Dizziness (3-9%)
- Dyspepsia (3-9%)
- Epigastric pain (3-9%)
- Indigestion (3-9%)
- Nausea (3-9%)
- Symptomatic upper GI ulcers, gross bleeding/perforation (4% of patients treated for 1 year, 1% of patients treated for 3-6 months)
- Abnormal pain/cramps/distress (Less than 3%)
- Constipation (1-3%)
- Depression (1-3%)
- Diarrhea (1-3%)
- Fatigue (1-3%)
- Somnolence (1-3%)
- Tinnitus (1-3%)
- Vertigo (1-3%)
- Acute interstitial nephritis with hematuria/proteinuria
- Acute respiratory distress
- Agranulocytosis
- Angioedema
- Aplastic anemia
- Asthma
- Bone marrow depression
- Congestive heart failure (CHF)
- Hemolytic anemia
- Leukopenia
- Macular and morbilliform eruptions
- Pulmonary edema
- Thrombocytopenia
- Thrombocytopenic purpura
- Ulcerative stomatitis
- Urticaria
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Methotrexate
|
May increase plasma levels
|
|
Warfarin
|
Increased risk of GI bleeding
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Ulcer
|
Can cause dangerous bleeding
|
|
Gastritis
|
Can worsen stomach inflammation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place protected from light. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.