Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ventricular Arrhythmias |
Dose: Intravenous – 1-1.5 mg/kg Frequency: slow intravenous bolus over 2-3 minutes Note: May repeat doses of 0.5-0.75 mg/kg in 5-10 minutes up to 3 mg/kg total. Hepatic impairment: Dosage reduction may be needed. |
|
Indication: Ventricular Arrhythmias |
Dose: Intravenous – 1-4 mg/min Frequency: continuous infusion Note: Hepatic impairment: Dosage reduction may be needed. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Ventricular Arrhythmias |
Dose: Bolus – 0.5-1 mg/kg Note: Intravenous/Intraosseous/Endotracheal; not to exceed 100 mg; follow with continuous infusion; if delay between bolus and start of infusion is greater than 15 minutes, administer a second bolus every 5-10 minutes to 5 mg/kg |
|
Indication: Ventricular Arrhythmias |
Dose: Continuous infusion – 20-50 mcg/kg/min Note: Intravenous |
Administration
- Hospital use only
- Given by healthcare provider
Side Effect
- Cardiovascular Hypotension
- Dermatologic Edema
- erythema at injection site
- petechiae
- skin irritation
- Gastrointestinal Constipation
- Nausea
- vomiting
- Neurologic Confusion
- dizziness
- headache
- paresthesia
- somnolence
- tremor
- Other Irritation symptom
- Topical products
- ie
- erythema
- edema
- Cardiovascular Cardiac arrest
- cardiac dysrhythmia
- Hematologic Methemoglobinemia
- Neurologic Seizure
- Anaphylactoid reactions
- Malignant hyperthermia
- Hypotension and bradycardia leading to cardiac arrest
- anaphylaxis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cimetidine, Propranolol
|
May increase serum levels
|
|
Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol), Other Antiarrhythmics (Amiodarone, Flecainide, Propafenone, Quinidine, Disopyramide, Procainamide)
|
Increased risk of cardiac depression
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypovolaemia
|
Risk of cardiovascular collapse
|
|
Heart block
|
Can worsen conduction problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.