Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Malaria Age: Adult |
Dose: Oral – 648 mg Frequency: every 8 hours Duration: 7 days Note: As sulfate |
|
Indication: Nocturnal leg cramps Age: Adult |
Dose: Oral – 200-300 mg Frequency: once at night |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Malaria Age: greater than 8 years |
Dose: Oral: As sulfate – 10 mg/kg Frequency: every 8 hours Duration: 7 days |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Severe (Initial) |
Dose: Tablet – 648 mg Frequency: once Note: followed after 12 hours by maintenance doses |
|
Condition: Renal impairment: Severe (Maintenance) |
Dose: Tablet – 324 mg Frequency: every 12 hours |
Administration
- Take with food
- Take with food to minimize stomach upset
Side Effect
- Flushing of the skin
- Anginal symptoms
- Fever
- Rash
- Pruritus
- Hypoglycemia
- Epigastric pain
- Hemolysis in G6PD deficiency
- Thrombocytopenia
- Hepatitis
- Nightblindness
- Diplopia
- Optic atrophy
- Impaired hearing
- Hypersensitivity reaction
- Severe headache
- Nausea
- Vomiting
- Diarrhea
- Blurred vision
- Sinus arrest
- AV block
- ventricular fibrillation and sudden death especially with IV use
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Amantadine
|
Reduced renal clearance
|
|
Cimetidine
|
Reduced clearance
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Myasthenia Gravis
|
Can worsen muscle weakness
|
|
Black Water Fever
|
Can worsen condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.