Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – 5 mg/day Frequency: once daily initially Note: may be increased by 2.5 mg/day every 7-14 days; not to exceed 10 mg/day; maintenance: 5-10 mg/day; Adjust dosage according to blood pressure goals |
|
Indication: Angina & Coronary Artery Disease Age: Adult Condition: chronic stable angina, vasospastic angina (Prinzmetal or variant angina), and angiographically documented coronary artery disease in patients without heart failure or ejection fraction less than 40% |
Dose: Oral – 5-10 mg/day Frequency: once daily initially Note: maintenance: 10 mg/day by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: less than 6 years |
Dose: Tablet – Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: Hypertension Age: 6-17 years |
Dose: Tablet – 2.5-5 mg/day Frequency: once daily Note: by mouth (oral); doses above 5 mg/day have not been studied; lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: The Pharmacokinetics of amlodipine are not significantly affected by renal impairment; therefore no dosage adjustment necessary |
Administration
- Take with or without food
- Take at same time daily
Side Effect
- Edema (1.8-10.8%)
- Pulmonary edema (7-15%)
- Headache (7.3%)
- Fatigue (4.5%)
- Palpitations (0.7-4.5%)
- Dizziness (1.1-3.4%)
- Nausea (2.9%)
- Flushing (0.7-2.6%)
- Abdominal pain (1.6%)
- Somnolence (1.4%)
- Male sexual disorder (1-2%)
- Drowsiness (1%)
- Pruritus (1-2%)
- Skin rash (1-2%)
- Muscle cramps (1-2%)
- Muscle weakness (1-2%)
- Hypotension
- bradycardia
- conductive system delay and CCF
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A4 inhibitors (e.g. Azole Antifungals (Fluconazole, Itraconazole, Ketoconazole, Voriconazole, Posaconazole), ritonavir)
|
Plasma concentrations may be elevated
|
|
Simvastatin
|
May increase risk of myopathy including rhabdomyolysis
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Hypertension
|
May not be adequate alone
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep all medicines out of reach of children. Store in a cool & dry place, protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.