Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Induction of anaesthesia Age: Adult |
Dose: Intravenous injection – 1-4.5 mg/kg Frequency: once Note: Administer via slow intravenous injection over 60 seconds. A dose of 2 mg/kg produces surgical anaesthesia within 30 seconds after injection lasting for 5-10 minutes. |
|
Indication: Maintenance of anaesthesia Age: Adult |
Dose: Intravenous injection – Increments of half to the full induction dose Note: May be repeated as needed for maintenance of anesthesia. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Induction of anesthesia Age: 3 months to 16 years |
Dose: intravenous – 1–2 mg/kg Note: intravenous |
|
Indication: Induction of anesthesia Age: 3 months to 16 years |
Dose: intramuscular – 4–6 mg/kg Note: intramuscular |
Administration
- For hospital use only
- Must be diluted properly
Side Effect
- Emergence rxns (Emergence reactions eg vivid dreams, hallucinations, confusion, irrational behaviour)
- HTN
- Increased cardiac output
- Increased ICP
- Tachycardia
- Tonic-clonic movements
- Visual hallucinations
- Bradycardia
- Diplopia
- Hypotension
- Increased IOP
- Injection-site pain
- Nystagmus
- Anaphylaxis
- Cardiac arrhythmia
- Depressed cough reflex
- Fasciculations
- Hypersalivation
- Increased IOP
- Increased metabolic rate
- Hypertonia
- Laryngospasm
- Respiratory depression or apnea with large doses or rapid infusions
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Barbiturates, narcotics
|
Prolonged recovery time
|
|
Atracurium, tubocurarine
|
May potentiate neuromuscular blocking effects including respiratory depression with apnoea
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypertension
|
Risk of dangerous BP elevation
|
|
History of cerebrovascular accident
|
Risk of brain complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.