Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Treatment of acute gout flares |
Dose: Tablet – 1.2 mg Frequency: by mouth at first sign of flare, then 0.6 mg 1 hour later Note: Not to exceed 1.8 mg in 1-hour period |
|
Indication: Prophylaxis of gout flares |
Dose: Tablet – 0.6 mg Frequency: by mouth once daily or every 12 hours Note: Not to exceed 1.2 mg/day; after gout flare, wait 12 hours to continue prophylaxis |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Gout Age: less than 16 years |
Dose: Oral – Not recommended Note: Not recommended |
|
Indication: Treatment of acute gout flares Age: greater than 16 years |
Dose: Oral – 1.2 mg Frequency: at first sign of flare, then 0.6 mg 1 hour later Note: not to exceed 1.8 mg in 1-hour period; by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Gout Condition: Renal impairment, Mild (CrCl 50-80 mL/min) and moderate (CrCl 30-50 mL/min) |
Dose: Tablet – Dosage adjustment not necessary Note: Monitor patients for adverse effects |
|
Indication: Gout Condition: Renal impairment, Severe (CrCl less than 30 mL/min) |
Dose: Tablet – Dosage adjustment not necessary Note: Do not repeat more frequently than every 2 weeks |
Administration
- Take with or without food
- Take with water
Side Effect
- Gastrointestinal (GI) effects (eg diarrhea, nausea, cramping, abdominal pain, vomiting) (26-77%)
- Fatigue (1-4%)
- Gout (0-4%)
- Pharyngolaryngeal pain (2-3%)
- Headache (1-2%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Vitamin B12
|
Reversible malabsorption may occur
|
|
CNS depressants, Sympathomimetics (Ephedrine, Pseudoephedrine, Phenylephrine)
|
Response may increase when used concurrently
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Debilitated Patients
|
Risk of increased toxicity
|
|
Blood Dyscrasias
|
Can worsen blood disorders
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 30°C temperature. Protect from light and moisture. Keep the medicine out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.