Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – Initially, 100 mg Frequency: twice daily Note: May increase gradually according to patients response to 200-400 mg twice daily. Maximum: 2.4 g/day in 2-4 divided doses. |
|
Indication: Hypertension Age: Elderly |
Dose: Oral – Initially, 50-100 mg Frequency: twice daily Note: Maintenance: 100-200 mg twice daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertensive Emergency |
Dose: Continuous Intravenous Infusion – 0.4-1 mg/kg/hour Note: Not to exceed 3 mg/kg/hour |
Administration
- Take with food
- Take immediately after meals
Side Effect
- Dizziness (1-20%)
- Lightheadedness (1-20%)
- Nausea (Less than 19%)
- Tingling sensation of scalp (4-12%)
- Elevated serum blood urea nitrogen (BUN) (Less than 8%)
- Elevated serum creatinineeatinine (8%)
- Congestion of nasal sinus (1-6%)
- Orthostatic hypotension (1-5%)
- Absence of ejaculation (Less than 5%)
- Paresthesia (Less than 5%)
- Elevated liver enzymes (4%)
- Diaphoresis (Less than 4%)
- Edema (Less than 2%)
- Bronchospasm (1-2%)
- Dyspnea (1-2%)
- Pruritus (1%)
- Rash (1%)
- Altered taste sense (1%)
- Ventricular arrhythmia (1% IV)
- Angioedema
- Bradycardia
- Alopecia
- Cholestatic jaundice
- Depression
- Diabetes insipidus
- Hepatitis
- Raynaud syndrome
- Toxic myopathy
- Urinary retention
- Urticaria
- Raynaud phenomenon
- Hepatic injury
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Halothane
|
Synergistic hypotensive effect
|
|
Cimetidine
|
Increased absolute bioavailability
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
2nd degree heart block
|
Can cause complete heart block
|
|
3rd degree heart block
|
Can worsen heart conduction
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool & dry place protected from light. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.