Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – 50 mg Frequency: once daily Note: May increase to 100 mg/day as single dose or in 2 divided doses if needed. |
|
Indication: Hypertension Age: Adult Condition: Intravascular volume depletion |
Dose: Oral – 25 mg Frequency: once daily Note: Initial dose. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: less than 6 years |
Dose: Dosage Form – Not established Note: Safety and efficacy not established |
|
Indication: Hypertension Age: Child: greater than 6 years |
Dose: Dosage Form – Initially, 0.7 mg/kg Note: Maximum: 50 mg/day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance less than 20 ml/min |
Dose: 25 mg Frequency: once daily Note: Initially 25 mg once daily |
Administration
- Can take with/without food
- Regular timing
Side Effect
- Fatigue (14%)
- Hypoglycemia (14%)
- Anemia (14%)
- Urinary Tract Infection (UTI) (13%)
- Chest pain (12%)
- Weakness (14%)
- Diarrhea (2-15%)
- Cough
- incidence higher in previous cough related to angiotensin-converting enzyme (ACE) inhibitor therapy (3-11%)
- Upper respiratory tract infection (URTI) (8%)
- Hypotension (7%)
- Dizziness (4%)
- Cellulitis (7%)
- Gastritis (5%)
- Nausea (2%)
- Angioedema
- Edema/swelling
- Hypotension in hypovolemic or diuretic-using
- patients
- Asthenia
- Headache
- Malaise
- Nausea
- Abdominal pain
- Hyperkalemia
- Back pain
- Worsening renal failure
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Fluconazole, Rifampicin
|
May decrease plasma levels
|
|
Lithium
|
May increase serum lithium levels and toxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity to active ingredient
|
Risk of allergic reaction
|
|
Diabetes with renal impairment
|
Risk of kidney failure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
keep in a dry place away from light and heat. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.