Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Community-Acquired Pneumonia |
Dose: by mouth/intravenous – 500 mg Frequency: once daily Duration: 7-14 days |
|
Indication: Community-Acquired Pneumonia |
Dose: by mouth/intravenous – 750 mg Frequency: once daily Duration: 5 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: postexposure anthrax prophylaxis Age: Children |
Dose: by mouth (oral) or intravenous – 16 mg/kg/day Frequency: divided every 12 hours |
|
Indication: postexposure anthrax prophylaxis Age: Children |
Dose: by mouth (oral) or intravenous – 500 mg Frequency: once daily Note: every 12 hours |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Haemodialysis/CAPD |
Dose: Tablet – Initially, 500 mg, then 250 mg Frequency: every 48 hours Note: Alternatively: Initially, 750 mg daily, then 500 mg every 48 hours. |
|
Condition: Creatinine Clearance 20-49 ml/min |
Dose: Tablet – Initially, 500 mg, then 250 mg Frequency: every 24 hours Note: Alternatively: Initially, 750 mg daily, then 750 mg every 48 hours. |
Administration
- Take on empty stomach
- Space from antacids
Side Effect
- Nausea (7%)
- Headache (6%)
- Diarrhea (5%)
- Insomnia (4%)
- Constipation (3%)
- Dizziness (3%)
- Dyspepsia (2%)
- Rash (2%)
- Vomiting (2%)
- Chest pain (1%)
- Dyspnea (1%)
- Edema (1%)
- Fatigue (1%)
- Injection-site reaction (1%)
- Moniliasis (1%)
- Pain (1%)
- Pruritus (1%)
- Vaginitis (1%)
- Cardiac Cardiac arrest
- palpitation
- ventricular tachycardia
- arrhythmia
- Nervous system Tremor
- convulsions
- paresthesia
- vertigo
- hypertonia
- hyperkinesias
- abnormal gait
- somnolence
- syncope
- Metabolic Hypoglycemia
- hyperglycemia
- hyperkalemia
- Blood/lymphatic system Anemia
- thrombocytopenia
- granulocytopenia
- Musculoskeletal/connective tissue Arthralgia
- tendonitis
- myalgia
- skeletal pain
- Gastrointestinal (GI) Gastritis
- stomatitis
- pancreatitis
- esophagitis
- gastroenteritis
- glossitis
- pseudomembranous/C difficile colitis
- Hepatobiliary Abnormal hepatic function
- increased hepatic enzymes
- increased alkaline phosphatase
- Psychiatric Anxiety
- agitation
- confusion
- depression
- hallucinations
- nightmares
- sleep disorder
- anorexia
- abnormal dreaming
- Other Immune hypersensitivity reaction
- acute renal failure
- urticaria
- phlebitis
- epistaxis
- Anaphylaxis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Quinidine, Procainamide, Amiodarone, Sotalol, Fluoxetine, Imipramine
|
Additive effects on QT interval prolongation
|
|
Sucralfate, Didanosine, Antacids containing Mg or Al, Dietary supplements containing Zn, Ca, Mg or Fe
|
Reduced absorption
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.