Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Type 2 diabetes mellitus Age: Adult Condition: Initial dose |
Dose: Oral – 1-2 mg Frequency: once daily Note: May be increased in increments of 1-2 mg at intervals of 1-2 weeks. Severe hepatic impairment is contraindicated. |
|
Indication: Type 2 diabetes mellitus Age: Adult Condition: Maintenance dose |
Dose: Oral – 4 mg Frequency: once daily Note: Severe hepatic impairment is contraindicated. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Tablet – 1 mg Frequency: once daily Note: by mouth; titrate dose based on fasting blood glucose levels |
|
Condition: Severe renal impairment |
Dose: Tablet Note: Contraindicated. |
Administration
- Take with first meal
- Regular timing
Side Effect
- Hypoglycemia (4-20%)
- Dizziness (1.7%)
- Asthenia (1.6%)
- Headache (1.5%)
- Nausea (1.1%)
- Allergic skin reactions
- Erythema
- Morbilliform or maculopapular eruptions
- Pruritus
- Urticaria
- Diarrhea
- Gastrointestinal pain
- Vomiting
- Agranulocytosis
- Anemia
- Aplastic anemia
- Leukopenia
- Pancytopenia
- Thrombocytopenia
- hemolytic
- Cholestasis
- Elevation of liver enzyme levels
- Hepatic porphyria reactions
- Jaundice (rare)
- Disulfiram-like reactions
- Hyponatremia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Salicylates, Sulfonamides, Chloramphenicol, Clarithromycin, Coumarin Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban), Probenecid, CYP2C9 inhibitors, Fibric acid derivatives, Disopyramide, Fluoxetine, Quinolones, ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide), β-blockers
|
May potentiate the hypoglycaemic action
|
|
Thiazides and other diuretics, Corticosteroids (Prednisone, Prednisolone, Methylprednisolone, Dexamethasone, Hydrocortisone), Phenothiazines, Thyroid products, Oestrogens, Phenytoin, Nicotinic acid, Sympathomimetics (Ephedrine, Pseudoephedrine, Phenylephrine), CYP2C9 inducers
|
May reduce hypoglycaemic effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Diabetic Ketoacidosis With Or Without Coma
|
Can worsen metabolic state
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.