Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prevention of Cardiovascular Disease Condition: Hypertension/Angina |
Dose: Tablet – 2.5-10 mg amlodipine; 10-80 mg atorvastatin Frequency: once daily Note: Dosage must be individualized; amlodipine dose may be titrated after 1-2 weeks and the atorvastatin dose after 2-4 weeks; not to exceed 10 mg amlodipine or 80 mg atorvastatin; administered by mouth |
|
Indication: Hyperlipidemia |
Dose: Tablet – 2.5-10 mg amlodipine; 10-80 mg atorvastatin Frequency: once daily Note: Dosage must be individualized; amlodipine dose may be titrated after 1-2 weeks and the atorvastatin dose after 2-4 weeks; not to exceed 10 mg amlodipine or 80 mg atorvastatin; administered by mouth |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension & Heterozygous Familial Hypercholesterolemia Age: less than 10 years |
Dose: Tablet – Safety and efficacy not established Note: Safety and efficacy not established |
|
Indication: Hypertension & Heterozygous Familial Hypercholesterolemia Age: greater than 10 years |
Dose: Tablet – 2.5-5 mg amlodipine; 10-20 mg atorvastatin Frequency: once daily Note: by mouth (oral); Dosage must be individualized for each individual component; amlodipine dose may be titrated after 1-2 weeks and the atorvastatin dose after 2-4 weeks; not to exceed 5 mg amlodipine or 20 mg atorvastatin |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment |
Dose: Dose adjustment not necessary Note: Renal function status should be monitored according to clinical guidelines. |
Administration
- Take with or without food
- Take at same time daily
Side Effect
- Peripheral edema (2-15%)
- Arthralgia (4-12%)
- Diarrhea (5-14%)
- Nasopharingitis (4-13%)
- Palpitation (1-5%)
- Dizziness (1-3%)
- Flushing (1-5%)
- Somnolence (1-2%)
- Rash (1-2%)
- Fatigue (5%)
- Pruritus (1-2%)
- Male sexual dysfunction (1-2%)
- Nausea (3%)
- Dyspepsia (1-2%)
- Dyspnea (1-2%)
- Weakness (1-2%)
- Nausea (4-7%)
- Dyspepsia (3-6%)
- Increased transaminases (2-3% with 80 mg/day)
- Urinary Tract Infection (UTI) (4-8%)
- Insomnia (1-5%)
- Myalgia (3-8%)
- Musculoskeletal pain (2-5%)
- Respiratory pharyngeal pain (1-4%)
- Amlodipine
- Abnormal vision
- Arthralgia
- Chest pain
- Abnormal dreams
- Increased apetite
- Acute interstitial nephritis
- Alopecia
- Conjunctivitis
- Cough
- Depression
- Dysphagia
- Flatulence
- Amnesia
- Alopecia
- Anorexia
- Colitis
- Confusion
- Bullous rash
- Biliary pain
- Anemia
- Cholestatic jaundice
- Duodenal ulcer
- Rhabdomyolysis with acute renal failure
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifamycins
|
Increases metabolism of both Amlodipine and Atorvastatin
|
|
Fibric acid derivatives, Niacin (lipid-modifying doses), Cyclosporine, Clarithromycin, HIV Protease Inhibitors (Ritonavir, Atazanavir, Lopinavir, Nelfinavir, Saquinavir, Indinavir), Itraconazole
|
Potentially Fatal: Increased risk of myopathy with Atorvastatin
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Liver Disease
|
Risk of liver damage
|
|
Elevated Hepatic Transaminases
|
Risk of liver complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Protect from light and moisture. Keep all medicines out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.