Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension |
Dose: Oral – 2.5-5 mg Frequency: once daily Note: Initial dose |
|
Indication: Hypertension |
Dose: Oral – 10-40 mg/day Frequency: once daily or divided every 12 hours Note: Maintenance dose |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: 1 month to 16 years |
Dose: Oral - 0.08 mg/kg/day Frequency: once daily or divided every 12 hours Note: by mouth (oral); not to exceed 5 mg/day; may increase as needed every 2 weeks according to blood pressure not to exceed 0.58 mg/kg/day (or 40 mg/day) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: creatinine clearance less than 30 mL/min Condition: Renal impairment |
Dose: by mouth – Initiate 2.5 mg Note: titrate to response; not to exceed 40 mg |
|
Condition: Dialysis |
Dose: by mouth – 2.5 mg Frequency: on day of dialysis Note: adjust dose on nondialysis days according to blood pressure |
Administration
- Take with or without food
- Take at same time each day
Side Effect
- Dizziness (4-8%)
- Hypotension (0.9-6.7%)
- Headache (2-5%)
- Chest pain (2%)
- Cough (1-2%)
- Rash (1.5%)
- Asthenia
- Nausea
- Vomiting
- Hyperkalemia
- Angioedema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene), Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil), TCAs, Nitrates, Anaesthetics
|
May potentiate hypotensive action
|
|
Lithium carbonate
|
May cause lithium toxicity
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of Angioedema due to Previous Treatment with ACE Inhibitors
|
Risk of life-threatening swelling
|
|
Bilateral Renal Artery Stenosis
|
Can worsen kidney function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.