Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Progestogen component of menopausal hormonal replacement therapy Age: Adult |
Dose: Oral – 200 mg Frequency: once daily at night Duration: 12-14 days of each month |
|
Indication: Amenorrhoea Age: Adult |
Dose: Oral – 400 mg Frequency: once daily Duration: 10 days |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved dosage available Note: No approved pediatric dosage available |
Administration
- Take at the same time every day
- Follow prescribed schedule exactly
Side Effect
- Headache (10-31%)
- Breast tenderness (16-27%)
- Dizziness (15-24%)
- Abdominal pain (10-20%)
- Depression (19%)
- Breast pain (6-16%)
- Viral disease (7-12%)
- Vaginal discharge (10%)
- Fatigue (8-9%)
- Nausea (8%)
- Mood swings (6%)
- Dementia
- probable(postmenopausal women More than 65 years of age
- possible association)
- Anorexia
- Weakness
- Weight change (less common than with synthetic progestins)
- Vomiting
- Edema
- DVT (postmenopausal women 50-79 years of age)
- Thrombophlebitis
- Myocardial infarction (postmenopausal women 50-79 years of age)
- Stroke (postmenopausal women 50-79 years of age)
- Pulmonary emboli (postmenopausal women 50-79 years of age)
- Amenorrhea (less common than with synthetic progestins)
- Breakthrough bleeding (less common than with synthetic progestins)
- Change in menstrual flow(less common than with synthetic progestins)
- Spotting (less common than with synthetic progestins)
- Breast changes (less common than with synthetic progestins)
- Invasive breast cancer(postmenopausal women 50-79 years of age)
- Cholestatic jaundice
- Vaginal candidiasis
- General pruritus
- Ectopic pregnancy
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
No interactions listed
|
-
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Thrombophlebitis
|
Increases blood clot risk
|
|
Cerebral Apoplexy
|
Risk of stroke complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.