Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Pain Age: Adults |
Dose: Oral – 500 mg initially, then 250 mg Frequency: every 6 to 8 hours or 500 mg every 12 hours as needed Note: Not to exceed 1250 mg/day naproxen base on day 1; subsequent daily doses should not exceed 1000 mg naproxen base |
|
Indication: Pain Age: Adults |
Dose: Extended release – 750-1000 mg Frequency: once daily Note: May temporarily increase to 1500 mg/day if tolerated well and clinically indicated |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Pain Age: greater than 12 years |
Dose: Tablet – 500 mg initially, then 250 mg Frequency: every 6 to 8 hours Note: by mouth (oral), as needed; not to exceed 1250 mg/day naproxen base on day 1; subsequent daily doses should not exceed 1000 mg naproxen base |
|
Indication: Pain Age: greater than 12 years |
Dose: Tablet – 500 mg initially, then 500 mg Frequency: every 12 hours Note: by mouth (oral), as needed; not to exceed 1250 mg/day naproxen base on day 1; subsequent daily doses should not exceed 1000 mg naproxen base |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance less than 30 mL/min |
Dose: Use not recommended Note: Severe: Contraindicated. |
Administration
- Take with food
- Take with full glass of water
Side Effect
- Abdominal pain (3-9%)
- Constipation (3-9%)
- Dizziness (3-9%)
- Drowsiness (3-9%)
- Headache (3-9%)
- Heartburn (3-9%)
- Nausea (3-9%)
- Edema (3-9%)
- GI bleeding (1-4%)
- GI perforation (1-4%)
- Lightneadedness (Less than 3%)
- GI ulcers (1-4%)
- Fluid retention (3-9%)
- Diarrhea (1-3%)
- Stomatitis (Less than 3%)
- Diverticulitis (1-3%)
- Dyspnea (3-9%)
- Hearing disturbances (Less than 3%)
- Meaningful (3 × upper limit of normal) elevation of serum alanine aminotransferase or aspartate aminotransferase
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Methotrexate
|
May enhance toxicity
|
|
ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Angiotensin II receptor antagonists
|
Reduced BP response
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Perioperative Pain In The Setting Of CABG Surgery
|
Increases risk of bleeding and cardiovascular events during and after surgery
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.