Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chemotherapy Induced Nausea and Vomiting Age: Adult |
Dose: Oral – 1 mg Frequency: by mouth 1 hour before chemotherapy, then 1 mg 12 hours after 1st dose; OR 2 mg 1 hour before chemotherapy |
|
Indication: Chemotherapy Induced Nausea and Vomiting Age: Adult |
Dose: Intravenous – 0.01 mg/kg/dose Note: infused over 5 minutes or direct injected over 30 seconds, 30 minutes before chemotherapy |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chemotherapy Induced Nausea and Vomiting Age: less than 2 years |
Dose: intravenous – Dosage not established Note: Safety and efficacy not established |
|
Indication: Chemotherapy Induced Nausea and Vomiting Age: 2-16 years |
Dose: intravenous – 0.01 mg/kg Note: infused over 5 minutes or direct injection over 30 seconds, 30 minutes before chemotherapy |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Severe (creatinine clearance less than 30 mL/minute) |
Dose: Intravenous – 40 mcg/kg Note: Total clearance was not affected in patients with severe renal failure who received a single dose |
|
Condition: Renal impairment |
Dose: By mouth – No dosage adjustment required Note: No dosage adjustment required |
Administration
- Take up to 1hr before chemotherapy
- Can take with/without food
Side Effect
- Headache (10-21%)
- Diarrhea (1-9%)
- Constipation (3-18%)
- Asthenia (5%)
- Somnolence (10%)
- Sedation (10%)
- Drowsiness (10%)
- Anxiety
- Fatigue
- Malaise
- Increased LFTs
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Phenobarbital
|
May induce metabolism of granisetron
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 15-30°C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.