Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Partial Seizures Condition: Adjunctive therapy for partial seizures with or without secondary generalization |
Dose: by mouth – Initial: 300 mg Frequency: every 8 hours Note: May increase up to 600 mg by mouth every 8 hours; up to 2400 mg/day administered and tolerated in clinical studies; up to 3600 mg administered for short duration and tolerated |
|
Indication: Postherpetic Neuralgia Condition: Day 1 |
Dose: by mouth – 300 mg Frequency: once daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Partial Seizures Age: less than 3 years |
Dose: PO – Dosage not established Note: by mouth (oral) |
|
Indication: Partial Seizures Age: 3-12 years Condition: Initial dose |
Dose: PO – 10-15 mg/kg/day Frequency: divided every 8 hours Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: by mouth – 300-1200 mg Frequency: three times daily |
|
Condition: Renal impairment |
Dose: by mouth – 200-700 mg Frequency: every 12 hours |
Administration
- Can take with/without food
- Take at evenly spaced times
Side Effect
- Ataxia (1-13%)
- Dizziness (16-20%)
- Drowsiness (5-21%)
- Fatigue (11-15%)
- Somnolence (16-20%)
- Diplopia (6-10%)
- Nystagmus (6-10%)
- Tremor (6-10%)
- Amblyopia (1-5%)
- Back pain (1-5%)
- Constipation (1-5%)
- Depression (1-5%)
- Dry mouth (1-5%)
- Dysarthria (1-5%)
- Dyspepsia (1-5%)
- Hostility (5-8% children)
- Hyperkinesia (3-5%)
- Increased appetite (1-5%)
- Leukopenia (1-5%)
- Myalgia (1-5%)
- Nervousness (1-5%)
- Peripheral edema (1-5%)
- Pharyngitis (1-5%)
- Pruritus (1-5%)
- Rhinitis (1-5%)
- Vasodilation (1-5%)
- Weight gain (1-5%)
- Abnormal vision (More than 1%)
- Anorexia (More than 1%)
- Arthralgia (More than 1%)
- Asthenia (More than 1%)
- HTN (More than 1%)
- Malaise (More than 1%)
- Paresthesia (More than 1%)
- Purpura (More than 1%)
- Vertigo (More than 1%)
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Morphine
|
May increase plasma level
|
|
Antacids
|
Reduced absorption
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 25°C temperature. Protect from light and moisture. Keep all the medicines out of the reach of the children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.