Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Diabetic gastric stasis Age: Adult |
Dose: Oral – 10 mg Frequency: 4 times daily Duration: 2-8 weeks Note: Severe Hepatic impairment: Reduce dose by 50% |
|
Indication: Nausea and vomiting associated with cancer chemotherapy or radiotherapy Age: Adult |
Dose: Oral – 10 mg Frequency: up to three times daily Duration: Maximum duration: 5 days Note: Severe Hepatic impairment: Reduce dose by 50% |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Small Bowel Intubation/Radiologic Examination of Upper GI Tract Age: less than 6 years old |
Dose: Intravenous – 0.1 mg/kg Duration: over 1-2 minutes |
|
Indication: Small Bowel Intubation/Radiologic Examination of Upper GI Tract Age: 6-14 years old |
Dose: Intravenous – 2.5-5 mg Duration: over 1-2 minutes |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance less than 40 mL/minute |
Dose: Not specified – decrease dose by 50% Note: Renal Dose adjustment: decrease dose by 50% |
|
Condition: Renal impairment: Creatinine Clearance less than 10 mL/minute |
Dose: Not specified – decrease dose by 75% Note: Renal Dose adjustment: decrease dose by 75% |
Administration
- Take on empty stomach
- Take 30 minutes before meals
Side Effect
- Extrapyramidal symptoms (dystonic reactions in 25% of young adults 18-30 years old)
- Fatigue (2-10%)
- Restlessness (10%)
- Sedation (10%)
- Headache (4-5%)
- Dizziness (1-4%)
- Somnolence (2-3%)
- Diarrhea
- Nausea
- Galactorrhea
- Gynecomastia
- Impotence
- Menstrual disorders
- Neuroleptic malignant syndrome
- Hematologic abnormalities
- Neuroleptic malignant syndrome
- cardiac conduction disorders may occur with IV dosage form
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CNS depressants
|
Increased sedative effects
|
|
Antimuscarinics (Atropine, Hyoscine, Ipratropium), Opioids
|
GI effects antagonised
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
GI Hemorrhage
|
Risk of increased bleeding
|
|
Mechanical Obstruction
|
Can mask serious condition
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25°C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.