Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Prevention of nausea and vomiting associated with highly emetogenic chemotherapy Age: Adult |
Dose: Oral Tablet – 24 mg Frequency: once Duration: 30 minutes before start of single-day chemotherapy |
|
Indication: Prevention of nausea and vomiting associated with moderately emetogenic chemotherapy Age: Adult |
Dose: Oral Tablet – 8 mg Frequency: administered 30 minutes before start of emetogenic chemotherapy, then a further dose after 8 hours of the first dose, then twice daily (every 12 hours) Duration: 1-2 days after completion of chemotherapy |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Moderate emetogenic cancer chemotherapy Age: 4-11 years |
Dose: Oral Tablet – 4 mg Frequency: first dose 30 minutes before chemotherapy, then 4 and 8 hours after first dose, then three times daily (every 8 hours) Duration: 1-2 days after completion of chemotherapy Note: first dose should be taken before the start of chemotherapy |
|
Indication: Prevention of nausea & vomiting associated with radiotherapy (Total body irradiation) Age: greater than 12 years |
Dose: Oral – 8 mg Frequency: once daily Note: 1-2 hours before each fraction of radiotherapy administered each day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Tablet – Fixed dose Note: Renal impairment: Dose adjustment not necessary |
Administration
- May be taken with or without food
- Take 30 minutes before chemotherapy
Side Effect
- Headache (9-27%)
- Malaise/fatigue (9-13%)
- Constipation (6-11%)
- Hypoxia (9%)
- Drowsiness (8%)
- Diarrhea (2-7%)
- Dizziness (7%)
- Fever (2-8%)
- Gynecologic disorder (7%)
- Anxiety (6%)
- Urinary retention (5%)
- Pruritus (2-5%)
- Injection-site pain (4%)
- Paresthesia (2%)
- Cold sensation (2%)
- Elevated liver function test results (1-5%)
- Cardiac Arrhythmias including ventricular and supraventricular tachycardia, premature ventricular contractions and atrial fibrillation
- bradycardia
- electrocardiographic alterations including second-degree heart block, QT/QTc interval prolongation and ST segment depression)
- palpitations
- syncope
- rarely and predominantly with intravenous ondansetron
- transient ECG changes including QT/QTc interval prolongation have been reported
- Gastrointestinal Nausea and vomiting
- Anaphylaxis
- ECG alterations Arrhythmias
- prolongation of PR
- QRS
- and QT intervals
- Hepatobiliary Specific hepatic enzyme abnormalities
- hepatic necrosis
- and abnormal hepatic function
- General Flushing
- rare cases of hypersensitivity reactions
- sometimes severe (eg anaphylactic reactions, angioedema, bronchospasm, cardiopulmonary arrest, hypotension, laryngeal edema, laryngospasm, shock, shortness of breath, stridor)
- Local reactions Pain
- redness
- and burning at injection site
- Lower respiratory Hiccups
- Neurological Oculogyric crisis appearing alone, as well as with other dystonic reactions
- transient dizziness during or shortly after intravenous infusion
- Skin and subcutaneous tissue Urticaria
- Stevens-Johnson syndrome
- and toxic epidermal necrolysis
- Eye Disorders Transient blindness (predominantly during IV administration) reported to resolve within a few minutes up to 48 hr
- transient blurred vision
- Musculoskeletal and connective tissue Arthralgia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Tramadol
|
May reduce analgesic effect
|
|
Rifampicin, CYP3A4 inducers
|
May reduce levels/effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Profound Hypotension
|
Can worsen low blood pressure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at temperature not exceeding 30ºC in a dry place. Protect from light and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.