Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic hepatitis C Age: Adult Condition: Monotherapy |
Dose: Subcutaneous Injection – 180 mcg Frequency: once weekly Duration: 48 weeks |
|
Indication: Chronic hepatitis C Age: Adult Condition: Dual therapy with Ribavirin (Genotype 1 & 4) |
Dose: Subcutaneous Injection – 180 mcg Frequency: once weekly Duration: 48 weeks |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic Hepatitis C Age: less than 5 years |
Dose: Subcutaneous Injection – 180 mcg/1.73 m² Note: Safety and efficacy not established |
|
Indication: Chronic Hepatitis C Genotypes 2, 3 Age: greater than 5 years Condition: Compensated liver disease |
Dose: Subcutaneous Injection – 180 mcg/1.73 m² Frequency: once weekly Duration: 24 weeks Note: Indicated in combination with daily ribavirin |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment with Creatinine Clearance 30-50 mL/minute |
Dose: Injection – 180 mcg Frequency: once weekly |
|
Condition: Renal impairment with Creatinine Clearance less than 30 mL/minute (including patients on hemodialysis) |
Dose: Injection – 135 mcg Frequency: once weekly |
Administration
- Inject subcutaneously once weekly
- Rotate injection sites
Side Effect
- Fatigue (24% to 67% )
- Headache (27% to 54% )
- Fever (24% to 54% )
- Myalgia (26% to 51% )
- Influenza-like illness (25% to 47% )
- Rigor (25% to 47% )
- Neutropenia (21% to 40% )
- Anxiety (19% to 33% )
- Feeling nervous (19% to 33% )
- Irritability (19% to 33% )
- Diarrhea (11% to 31% )
- Injection site inflammation (10% to 31% )
- Insomnia (19% to 30% )
- Arthralgia (22% to 28% )
- Alopecia (18% to 28% )
- Abdominal pain (8% to 26% )
- Nausea and vomiting (5% to 25% )
- Loss of appetite (16% to 24% )
- Injection site reaction (22% to 23% )
- Dizziness (13% to 23% )
- Depression (18% to 20% )
- Pruritus (12% to 19% )
- Dermatitis (8% to 16% )
- Weight decreased (4% to 16% )
- Lymphocytopenia (Severe) (5% to 14% )
- Anemia (2% to 14%)
- Lymphocyte count abnormal (3% to 14% )
- Reduced concentration (8% to 10% )
- Cough (4% to 10% )
- Dry skin (4% to 10% )
- Rash (5% to 8% )
- Thrombocytopenia (5% to 8% )
- Bacterial infectious disease (3% to 5%)
- Severe bacterial infection (1-3%) Less than 1% Angina
- Cardiac dysrhythmia
- Aggressive behavior
- Cerebral hemorrhage
- Cerebral ischemia
- Coma
- Drug Abuse
- Peripheral neuropathy
- Psychotic disorder
- Suicide
- Diabetes mellitus
- Colitis
- Gastrointestinal hemorrhage
- Pancreatitis
- Peptic ulcer disease
- Aplastic anemia
- Thrombotic thrombocytopenic purpura
- Abnormal liver function
- Cholangitis
- Liver failure
- Steatosis of liver
- Myositis
- Corneal ulcer
- Myocardial infarction
- Erythroderma (rare)
- Stevens-Johnson syndrome (rare)
- Hypo/hyperthyroidism
- Hypo/hyperglycemia
- Anemia (severe)
- Cytopenia (severe)
- Autoimmune disease (rare)
- Hypersensitivity reaction (severe)
- Serous retinal detachment
- Pulmonary infiltrates
- Liver graft rejection and renal graft rejection
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Ribavirin
|
Increased risk of haemolytic anemia, birth defects, foetal mortality, genotoxicity, mutagenicity
|
|
Theophylline
|
Decreases metabolism
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Autoimmune Hepatitis
|
Can worsen autoimmune condition
|
|
Decompensated Liver Disease
|
Risk of liver failure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in refrigerator at 2-8° C; do not freeze or shake. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.