Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression, Anxiety, Posttraumatic stress disorder Age: Adult |
Dose: Oral – 20 mg Frequency: once daily Note: Increase gradually, if necessary, by 10-mg increments weekly; maximum: 50 mg/day. |
|
Indication: Obsessive compulsive disorder, Social anxiety disorder Age: Adult |
Dose: Oral – 20 mg Frequency: once daily Note: Initially, 20 mg daily, increase weekly in 10-mg increments. Maintenance: 40-60 mg daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: Tablet – Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Severe renal impairment |
Dose: Tablet – 10 mg Frequency: once daily Note: Increase to a maximum of 40 mg once daily as necessary |
Administration
- May be taken with or without food
- Take in morning
Side Effect
- Nausea (15-24%)
- Insomnia (11-24%)
- Dry mouth (9-18%)
- Headache (17%)
- Asthenia (10-15%)
- Constipation (10-15%)
- Diarrhea (9-12%)
- Dizziness (6-14%)
- Ejaculation disorder (10-15%)
- Tremor (4-11%)
- Anxiety (5-10%)
- Blurred vision (5-10%)
- Decreased appetite (5-10%)
- Impotence (2-9%)
- Nervousness (2-5%)
- Paresthesia (2-5%)
- Hypertension
- Tachycardia
- Emotional lability
- Pruritus
- Weight gain
- Arthralgia
- Tinnitus
- Vertigo
- Depression exacerbation
- Mania (rare)
- Serotonin syndrome
- Suicidal thoughts (rare)
- Suicide (rare)
- Seizure (rare)
- Toxic epidermal necrolysis
- Hyponatremia (rare)
- Bleeding
- abnormal (rare)
- Acute hepatitis (rare)
- Stevens-Johnson Syndrome
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cyproheptadine, Phenytoin
|
Levels/effects inhibited
|
|
Carbamazepine, Cimetidine, CYP2D6 inhibitors
|
Levels/effects increased
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
MAOIs Use (within 14 days)
|
Risk of serotonin syndrome
|
|
Thioridazine Use
|
Risk of cardiac arrhythmias
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep out of the reach of children. Store at a cool and dry place. Protect from light and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.