Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Osteoarthritis |
Dose: Tablet – 50 mg/200 mcg or 75 mg/200 mcg Frequency: three times daily Note: Administer by mouth. Not to exceed 200 mcg misoprostol per dose or 800 mcg per day. A dosage of diclofenac higher than 150 mg per day is not recommended. Three times daily dose of misoprostol is more protective than when given twice daily. |
|
Indication: Rheumatoid Arthritis |
Dose: Tablet – 50 mg/200 mcg or 75 mg/200 mcg Frequency: three or four times daily Note: Administer by mouth. Not to exceed 200 mcg misoprostol per dose or 800 mcg per day. A dosage of diclofenac higher than 200 mg per day is not recommended. Three times daily dose of misoprostol is more protective than when given twice daily. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Tablet – Lowest effective dose Frequency: Lowest effective frequency Duration: Shortest possible duration Note: Avoid if possible or use with caution. Avoid in severe impairment. Monitor renal function; sodium and water retention may occur and renal function may deteriorate, possibly leading to renal failure. Diclofenac and misoprostol are primarily excreted by the kidneys. Long-term administration of NSAIDs has resulted in renal toxicity. Correct volume status in dehydrated or hypovolemic patients prior to initiating Diclofenac and misoprostol. Monitor renal function, especially during concomitant use of ACE inhibitors or ARBs. Also, monitor renal function in patients with hepatic impairment. Avoid the use of Diclofenac and misoprostol in patients with advanced renal disease. |
|
Condition: Advanced renal disease |
Dose: Tablet – Lowest dosage Duration: Shortest duration Note: If use cannot be avoided, monitor the patient's renal function and monitor for clinical signs of worsening renal function. |
Administration
- Take with food
- Do not chew or crush
Side Effect
- Rash including erythematous
- rash macular and maculo-papular (18%)
- Pyrexia (15%)
- Urticaria (13%)
- Flushing (13%)
- Hypertension (10%)
- Hyperhydrosis (8%)
- Decreased oxygen saturation (8%)
- Cough (8%)
- Tachypnea (8%)
- Tachycardia (8%)
- Urticaria (8%)
- Anaphylaxis (7%)
- Chest discomfort (7%)
- Muscle twitching (7%)
- Erythema (5%)
- Vomiting (5%)
- Rigors (5%)
- Pallor (5%)
- Cyanosis (5%)
- Agitation (5%)
- Tremor (5%)
- Myalgia (5%)
- Flushing (5%)
- Peripheral edema (3%)
- Pruritus (3%)
- Rash
- papular (3%)
- Throat tightness (3%)
- Fatigue
- Malaise
- Chills
- Edema
- Atrial fibrillation
- Congestive heart failure
- Myocardial infarction
- Phlebitis
- Vasculitis
- Syncope
- Dysphagia
- Enteritis
- Peptic ulcer
- Vaginitis
- Breast pain
- Dysmenorrhea
- Uterine cramping
- Ulcerative stomatitis
- Impotence
- Perineal pain
- Glycosuria
- Alopecia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Methotrexate
|
May increase serum levels
|
|
Other NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac), Anticoagulants (Warfarin, Heparin, Dabigatran, Rivaroxaban, Apixaban, Edoxaban) (e.g. warfarin)
|
Higher risk of GI bleeding
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Active Peptic Ulcer
|
Risk of bleeding
|
|
Asthma
|
Can trigger asthma attack
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place below 25º C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.