Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Parkinson Disease Age: Adult Condition: Immediate-release |
Dose: Oral – 0.125 mg Frequency: every 8 hours initially Note: gradually titrated upward at weekly intervals to target range of 1.5-4.5 mg/day by mouth divided every 8 hours |
|
Indication: Restless Legs Syndrome Age: Adult |
Dose: Oral – 0.125 mg/day Frequency: 2-3 hours before bedtime initially Note: may be increased every 4-7 days up to 0.5 mg/day (every 14 days if creatinine clearance 20-60 mL/min) |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Tablet – Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Parkinson disease Condition: Creatinine Clearance greater than 50 mL/min |
Dose: Immediate release – Dosage adjustment not necessary Note: Dosage adjustment not necessary |
|
Indication: Parkinson disease Condition: Creatinine Clearance 30-50 mL/min |
Dose: Immediate release – 0.125 mg Frequency: twice daily initially Note: not to exceed 0.75 mg three times daily |
Administration
- Can be taken with or without food
- May take with meals to reduce nausea
Side Effect
- Somnolence
- Dyskinesia
- Hallucinations
- Insomnia
- Dizziness
- Postural hypotension
- Nausea
- Abnormal dreams
- thoughts
- or vision
- Amnesia
- Confusion
- Paranoia or delusion
- Akathisia
- Asthenia
- Dry mouth
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Cimetidine
|
Inhibits active tubular secretion
|
|
Amantadine
|
Reduced clearance
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.