Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Bacterial endocarditis Age: Adult Condition: With aminoglycoside |
Dose: Intravenous – 1.2 g Frequency: every 4 hours |
|
Indication: Intrapartum prophylaxis against group B streptococcal infection Age: Adult |
Dose: Intravenous – Initial: 3 g, then 1.5 g Frequency: every 4 hours Duration: until delivery Note: Initial dose is 3 g, then 1.5 g every 4 hours until delivery. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Bacterial Infection Age: Infant & Children |
Dose: Intravenous – 100,000–250,000 U/kg/day Frequency: every 4–6 hours Note: Maximum daily dose is 24 million U. |
|
Indication: Bacterial Infection Age: Infant & Children |
Dose: Intramuscular – 100,000–250,000 U/kg/day Frequency: every 4–6 hours Note: Maximum daily dose is 24 million U. |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified – Not specified Note: Dosing interval should be no more frequent than every 8-10 hours |
Administration
- Hospital use only
- Given by injection
Side Effect
- uticaria
- fever
- joint pains
- rashes
- angioedema
- serum sickness-like reactions
- haemolytic anaemia
- interstitial nephritis
- neutropenia
- thrombocytopenia
- CNS toxicity including convulsions
- diarrhoea
- antibiotic-associated colitis
- Anaphylaxis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Probenecid
|
Increases and prolongs serum penicillin levels
|
|
Tetracycline
|
May antagonize the bactericidal effect of penicillin
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25°C. Reconstituted soln: Store between 2-8°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.