Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Surgery Premedication Age: Adult |
Dose: Intramuscular – 50-100 mcg/dose Frequency: 30-60 minutes prior to surgery |
|
Indication: Surgery Premedication Age: Adult |
Dose: Slow Intravenous – 50-100 mcg/dose Frequency: 30-60 minutes prior to surgery |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Preoperative medication, adjunct to general anesthesia, or adjunct to regional anesthesia Age: 2 to 12 years |
Dose: Intravenous – 2 to 3 mcg/kg Note: Intravenous administration |
|
Indication: Preoperative medication, adjunct to general anesthesia, or adjunct to regional anesthesia Age: 2 to 12 years |
Dose: Intramuscular – 2 to 3 mcg/kg Note: Intramuscular administration |
Administration
- Must be administered by healthcare professionals only
- Requires strict medical supervision
Side Effect
- Reduce pulmonary compliance and/or apnoea
- bronchoconstriction
- laryngospasm
- nausea
- vomiting
- bradycardia
- oedema
- CNS depression
- confusion
- dizziness
- drowsiness
- headache
- sedation
- hypotension
- peripheral vasodilation
- increased intracranial pressure
- itching
- rash
- erythema
- papules
- pruritus
- exfoliative dermatitis
- pustules
- macular rash
- gum bleeding and irritation
- taste perversion
- Dental cavities
- tooth loss
- gum line erosion
- throat irritation
- nasal ulcers
- epistaxis
- rhinorrhoea
- coughing
- urinary retention
- chest wall rigidity
- Transdermal Rash
- erythema and itching
- Respiratory depression
- trunk rigidity
- laryngospasm
- bronchoconstriction
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
CYP3A4 inhibitors (e.g. erythromycin, clarithromycin, troleandomycin, Azole Antifungals (Fluconazole, Itraconazole, Ketoconazole, Voriconazole, Posaconazole), ritonavir, amiodarone, nefazodone, aprepitant, diltiazem, verapamil)
|
Increases serum levels, may potentiate fatal respiratory depression
|
|
SSRIs, SNRIs, MAOIs (Phenelzine, Tranylcypromine, Selegiline, Moclobemide)
|
Increased risk of life-threatening serotonin syndrome
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25°C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.