Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension Age: Adult |
Dose: Oral – 4-8 mg Frequency: once daily or divided every 12 hours Note: Maximum: 16 mg/day by mouth divided every 12 hours |
|
Indication: Stable Coronary Artery Disease Age: Adult |
Dose: Oral – 4 mg Frequency: once daily Duration: for 2 weeks Note: THEN increase as tolerated to 8 mg/day by mouth divided every 12 hours to reduce risk of cardiovascular mortality or myocardial infarction in patients with stable coronary artery disease |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: No approved pediatric dosage available Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment with Creatinine Clearance less than 15 ml/min |
Dose: Dose – 2 mg Note: Administer on dialysis days |
|
Condition: Renal impairment with Creatinine Clearance 15-30 ml/min |
Dose: Dose – 2 mg Frequency: Every other day |
Administration
- Take before meals
- Take at same time daily
Side Effect
- Headache (23%)
- Cough (12%)
- Dizziness (8%)
- Back pain (6%)
- Lower extremity pain (5%)
- Abnormal ECG (2%)
- Palpitation (1%)
- Depression (2%)
- Somnolence (1%)
- Menstrual disorder (1%)
- Edema (4%)
- ALT increased (2%)
- Sexual dysfunction (male 1%)
- Sleep disorder (3%)
- Chest pain (2%)
- Nausea/vomiting (2%)
- Flatulence (1%)
- Rash (2%)
- Hyperkalemia (1%)
- Tinnitus (2%)
- Intestinal angioedema
- Liver failure (rare)
- Leukopenia
- Pruritus
- Stroke
- Syncope
- Urinary retention
- Vertigo
- Amnesia
- Angioedema
- More frequent in black patients (0.1%)
- Angioedema of lips
- More frequent in black patients (0.1%)
- Angioedema of throat
- More frequent in black patients (0.1%)
- Anaphylactoid reactions
- angioedema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene)
|
May enhance hypotensive effect
|
|
K supplements, Potassium-sparing diuretics (Amiloride, Eplerenone, Spironolactone, Triamterene), Other drugs (e.g. ciclosporin, heparin, indometacin)
|
Additive hyperkalaemic effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History of Angioedema
|
Risk of severe swelling
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Details coming soon
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.