Medicine Overview

Indication

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Adult Dose

Clinical InformationAdministration Information
Indication: Dry mouth after radiotherapy for malignant neoplasms of the head and neck
Age: Adult
Dose: Oral – 5 mg
Frequency: three times daily
Note: Initially 5 mg three times daily; if necessary, increase dose gradually after 4 weeks until adequate response is achieved; Maximum dose: 10 mg three times daily; Hepatic impairment: Reduce dose in moderate to severe cirrhosis.
Indication: Sjogren's syndrome
Age: Adult
Condition: For dry eyes and mouth
Dose: Oral – 5 mg
Frequency: 4 times daily
Note: Maximum dose: 30 mg daily; Stop treatment if no improvement after 3 months; Hepatic impairment: Reduce dose in moderate to severe cirrhosis.

Child Dose

Clinical InformationAdministration Information
Indication: Reduction of elevated intraocular pressure, Management of acute angle-closure glaucoma, Prevention of postoperative elevated intraocular pressure, Induction of miosis
Age: Children less than 2 years of age
Dose: Topical ophthalmic – One drop of 1% solution
Frequency: three times daily
Indication: Induction of miosis prior to goniotomy or trabeculotomy
Age: Children
Dose: Topical ophthalmic – One drop of 1% or 2% solution
Frequency: 15 to 60 minutes prior to surgery
Administration
  • May be taken with or without food
  • Take at evenly spaced intervals
Side Effect

Drug Interaction

Drug NameRisk Factors
Other miotics
Increased risk of toxic reactions
Aminoglycosides, Clindamycin, Colistin, Cyclopropane, Halogenated inhalational anaesthetics, Quinine, Procainamide, Lithium, Beta-blockers (Propranolol, Metoprolol, Atenolol, Bisoprolol, Carvedilol, Nadolol, Timolol, Sotalol)
May reduce efficacy of pilocarpine

Disease Interaction

Disease NameRisk Factors
Angle-Closure Glaucoma
Can worsen eye pressure
Acute Iritis
Can worsen inflammation

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage

Details coming soon

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.