Question 1

What is this medicine for, and how does it work?

Accepted Answer

This is a combination medication used to control Type 2 diabetes. It has two components: one increases insulin sensitivity and reduces glucose production in the liver, while the other increases insulin production and lowers blood glucose levels. It works in two different ways to control blood sugar.

Question 2

When and how should this medicine be taken?

Accepted Answer

• Take with meals • Take at the same time each day • Swallow whole with water • Complete the prescribed course

Question 3

When should this medicine not be used?

Accepted Answer

• In type 1 diabetes • In diabetic ketoacidosis • In severe kidney disease

Question 4

What precautions should be taken before using this medicine?

Accepted Answer

• Not for type 1 diabetes or diabetic ketoacidosis • Use caution with insulin and in liver problems • Monitor kidney function regularly • Avoid in severe kidney disease

Question 5

Is it safe to use this medicine during pregnancy?

Accepted Answer

• Use with caution during pregnancy • Limited data on combination use in pregnancy • Consult healthcare provider for individual assessment

Question 6

Can this medicine be used while breastfeeding?

Accepted Answer

• Not for type 1 diabetes or diabetic ketoacidosis • Use caution with insulin and in liver problems • Monitor kidney function regularly • Avoid in severe kidney disease

Question 7

Is this medicine suitable for children and elderly?

Accepted Answer

• Renal: Regular monitoring needed, especially in elderly

Question 8

What should be done if a dose is missed?

Accepted Answer

• If you miss a dose, take it as soon as you remember. • However, if it's almost time for your next dose, skip the missed dose. • Never take two doses together. • For twice-daily dosing: If more than 6 hours until your next dose, take the missed dose. • For once-daily dosing: If you remember on the same day, take the dose. • Take your next dose at the regular time. • If you miss multiple doses, contact your doctor.

Question 9

What should be done in case of an overdose?

Accepted Answer

• Symptoms: Lactic acidosis, hypoglycemia. • Treatment: Hemodialysis, glucose administration. • Complications: Renal failure.

Question 10

What should be done if side effects are experienced?

Accepted Answer

• Common side effects: Edema, diarrhea, nausea, dizziness, headache, urinary tract infection ** • What to do: Take with meals; Monitor blood sugar; Report swelling; Check kidney function; Stay hydrated; Stop taking the medication and seek medical advice if any severe side effect or unusual symptoms occur.

Question 11

What is Piomin 500 used for?

Accepted Answer

Piomin 500 (Metformin Hydrochloride + Pioglitazone) is a pharmaceutical medicine manufactured by Pacific Pharmaceuticals Ltd. in Bangladesh. It is primarily prescribed for Diabetes Mellitus Type 2.

Question 12

What is the active generic component of Piomin 500?

Accepted Answer

The active ingredient in Piomin 500 is Metformin Hydrochloride + Pioglitazone, belonging to the Combination Oral Hypoglycemic Preparations drug class.

Question 13

What is the retail price of Piomin 500 in Bangladesh?

Accepted Answer

The official retail price of Piomin 500 (Tablet) is ৳10.00 in Bangladesh (prices may vary slightly by pack size and authorized pharmacy).

Question 14

What is the recommended dosage for Piomin 500?

Accepted Answer

Standard adult dosage: Tablet – pioglitazone 15 mg and metformin 500 mg (twice daily). Pediatric dosage: Dose:. Always consult a registered physician for individualized dosage adjustments based on clinical assessment.

Question 15

Is Piomin 500 safe during pregnancy and breastfeeding?

Accepted Answer

Piomin 500 is classified under Pregnancy Category "Not Assigned". Always consult your healthcare provider or OB/GYN before taking this medication during pregnancy or lactation.

Question 16

What are the common side effects of Piomin 500?

Accepted Answer

**More than 10%**; Lower limb edema (2.9-11.3%);Upper respiratory infection (12-16); **1-10%**; Weight gain (2.9-6.7%);Diarrhea (4.8-5.8%);Nausea (3.6-5.8%);Urinary Tract Infection (UTI) (5.3-5.8%);Dizziness (4.8-5.4%);H

Clinical Information	Administration Information
Indication: Type 2 diabetes mellitus Age: Adult	Dose: Tablet – pioglitazone 15 mg and metformin 500 mg Frequency: twice daily Note: Initially, 15 mg/500 mg twice daily. Maximum: Pioglitazone 45 mg and metformin 2,550 mg daily. Hepatic impairment: Contraindicated.
Indication: Type 2 diabetes mellitus Age: Adult	Dose: Tablet – pioglitazone 15 mg and metformin 850 mg Frequency: once daily Note: Initially, 15 mg/850 mg once daily. Maximum: Pioglitazone 45 mg and metformin 2,550 mg daily. Hepatic impairment: Contraindicated.

Clinical Information	Administration Information
Indication: eGFR less than 30 mL/min/1.73 m² Condition: Renal impairment	Dose: Metformin – Not specified Note: Contraindicated; If eGFR falls below 30 mL/min/1.73 m² while taking metformin, discontinue the drug
Indication: eGFR 30-45 mL/min/1.73 m² Condition: Renal impairment	Dose: Metformin – Not specified Note: Not recommended to initiate treatment; Monitor eGFR at least annually or more often for those at risk for renal impairment (e.g., elderly)

Disease Name	Risk Factors
Renal Disease/Dysfunction	Impairs drug clearance
Cardiovascular Collapse	Risk of tissue hypoxia

Medicine Overview

Indication

What is this medicine for, and how does it work?

When and how should this medicine be taken?

When should this medicine not be used?

What precautions should be taken before using this medicine?

Is it safe to use this medicine during pregnancy?

Can this medicine be used while breastfeeding?

Is this medicine suitable for children and elderly?

What should be done if a dose is missed?

What should be done in case of an overdose?

What should be done if side effects are experienced?

Adult Dose

Child Dose

Renal Dose

Drug Interaction

Disease Interaction

Pregnancy

Data Sources