Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Induction of general anaesthesia Age: Adult |
Dose: Intravenous injection or infusion – 40 mg Frequency: every 10 seconds Note: Usual dose: 1.5-2.5 mg/kg. |
|
Indication: Maintenance of general anaesthesia Age: Adult |
Dose: Intravenous infusion – 4-12 mg/kg/hour Note: Or intermittent bolus injection of 20-50 mg. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Intravenous Anesthesia Induction Age: 3-16 years |
Dose: Intravenous – 2.5-3.5 mg/kg Note: Intravenous push over 20-30 seconds |
|
Indication: Maintenance Age: 2 months to 16 years |
Dose: Intravenous – 0.125-0.3 mg/kg/min Note: Intravenous infusion |
Administration
- For hospital use only
- Must be administered by healthcare professional
Side Effect
- Hypotension (peds 17%, adults 3-26%)
- Apnea lasting 30-60 sec (peds 10%, adults 24%)
- Apnea lasting More than 60 sec (peds 5%, adults 12%)
- Movement (peds 17%, adults 3-10%)
- Injection site burning/stinging/pain (peds 10%, adults 18%)
- Respiratory acidosis during weaning (3-10%)
- Hypertriglyceridemia (3-10%)
- Hypertension (peds 8%)
- Rash (peds 5%
- adults 1-3%)
- Pruritus (1-3%)
- Arrhythmia (1-3%)
- Bradycardia (1-3%)
- Cardiac output decreased (1-3%, concurrent opioid use increases incidence)
- Tachycardia (1-3%)
- Arterial hypotension
- Anaphylaxis
- Asystole
- Bronchospasm
- Cardiac arrest
- Seizures
- Opisthotic rxn
- Pancreatitis
- Pulmonary edema
- Phlebitis
- Thrombosis
- Renal tubular toxicity
- Apnoea
- bradycardia
- hypotension
- convulsions
- anaphylaxis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Nitrous oxide, Halogenated anaesthetics
|
Reduce dose
|
|
Other CNS depressants
|
Increased sedative, anaesthetic and cardiorespiratory effects
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Electroconvulsive Therapy
|
Interferes with seizure activity
|
|
Obstetrics
|
Risk to mother and fetus
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Propofol should be stored at a temperature not exceeding 25º C. It must not be frozen. Any unused solution shall be discarded.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.