Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Schizophrenia Age: Adult Condition: Immediate release |
Dose: Oral – Day 1: 50 mg/day; Days 2-3: increased daily in increments of 25-50 mg to 300-400 mg by day 4 Frequency: every 12 hours on Day 1, every 8-12 hours on Days 2-3 Note: further adjustments can be made in increments of 25-50 mg every 12 hours at intervals greater than 2 days; Dosage range: 150-750 mg/day |
|
Indication: Schizophrenia Age: Adult Condition: Extended release |
Dose: Oral – Day 1: 300 mg/day Note: subsequently, may be increased by up to 300 mg/day at intervals greater than 1 day; Maintenance (monotherapy): 400-800 mg/day; Patients who have discontinued therapy for greater than 1 week should have their dose retitrated following initiation of therapy; patients may reinitiate at their previous maintenance dose if discontinued therapy less than 1 week |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Schizophrenia Age: less than 12 years |
Dose: Not established Note: Safety and efficacy not established |
|
Indication: Schizophrenia Age: greater than 12 years Condition: monotherapy, immediate release |
Dose: Oral – 50 mg/day Frequency: divided every 12 hours Duration: Day 1 |
Administration
- Extended-release: Take without food or with light meal
- Regular tablets: Can be taken with or without food
Side Effect
- Dizziness (1-18%)
- Fatigue (3-14%)
- Extrapyramidal symptoms (1-13%)
- Increased diastolic blood pressure (41%)
- Increased triglycerides (8-22%)
- Increased total cholesterol (7-18%)
- Increased appetite (2-12%)
- Constipation (6-11%)
- Dry mouth (9-44%)
- Headache (7-21)
- Somnolence (18-57%)
- Abdominal pain (4-7%
- dose related)
- Dyspepsia (2-7%
- dose related
- Tremor (2-8%)
- Back pain (3-5%)
- Postural hypotension (2-7%)
- Tachycardia (1-6%)
- Pharyngitis (4-6%)
- Rhinitis (3-4%)
- Rash (4%)
- Blurred vision (1-4%)
- Arthralgia (1-4%)
- Myalgia (2%)
- Neck pain (2%)
- Dyskinesia (4%)
- Neutropenia (2%)
- Hemorrhage (1%)
- Priapism
- Cardiomyopathy
- myocarditis
- QTc prolongation
- Night mares
- Pancreatitis
- Rhabdomyolysis
- Palpitation
- Leukocytosis
- Epistaxis
- Exfoliative dermatitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Alcohol
|
Increased risk of drowsiness and postural hypotension
|
|
Phenytoin, Carbamazepine
|
May decrease plasma levels of quetiapine
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe CNS Depression
|
Can increase sedation dangerously
|
|
Bone Marrow Suppression
|
Affects blood cell production
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the blister pack and the carton. The expiry date refers to the last day of that month. Store in a cool and dry place away from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.