Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Congestive Heart Failure Condition: Immediate release |
Dose: Tablet – 3.125 mg Frequency: every 12 hours Duration: for 2 weeks, then increased every 2 weeks as tolerated to 6.25 mg, 12.5 mg, or 25 mg twice daily Note: Maximum recommended dosage (mild-to-moderate heart failure): weight less than 85 kg, 25 mg by mouth every 12 hours; weight greater than 85 kg: 50 mg by mouth twice daily. Maximum recommended dosage (severe heart failure): 25 mg by mouth twice daily. |
|
Indication: Congestive Heart Failure Condition: Extended release |
Dose: Capsule – 10 mg/day Frequency: once daily Duration: maintained for 1-2 weeks if tolerated Note: May be increased to 20 mg/day, 40 mg/day, or 80 mg/day by mouth if necessary. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Safety and efficacy not established |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: dosage form not specified – dose not specified Note: Renal impairment: No dosage adjustments necessary |
Administration
- Take with food
- Take at same time daily
Side Effect
- Dizziness (2-32%)
- Fatigue (4-24%)
- Hypotension (9-20%)
- Weight gain (10-12%)
- Hyperglycemia (5-12%)
- Diarrhea (1-12%)
- Bradycardia (2-10%)
- Nausea (2-9%)
- Cough (5-8%)
- Headache (5-8%)
- Atrioventricular block
- edema (1-7%)
- Angina (1-6%)
- Hpercholesterolemia (1-4%)
- Hypertriglyceredemia (1%)
- Vomiting (1-6%)
- Dyspnea (More than 3%)
- Syncope (3%)
- Rhinitis (2%)
- Hypertension
- Palpitations
- Insomnia
- Somnolence
- Skin rash
- Hepatotoxicity
- Impotence
- Bronchospasm
- Rales
- Depression
- Decreased exercise tolerance
- Raynaud phenomenon
- Increased triglyceride levels and insulin resistance with decreased high-density lipoprotein (HDL) levels
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Rifampicin
|
Decreased serum levels
|
|
Ca channel blockers (e.g. verapamil and diltiazem)
|
Can lead to bradycardia and myocardial depression
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Chronic Heart Failure
|
Can worsen heart failure symptoms
|
|
Bronchial Asthma
|
Can trigger severe breathing problems
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.