Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hypertension, Diabetic Nephropathy Age: Adult Condition: Initial (not on diuretic) |
Dose: Oral - 2.5 mg Frequency: once daily at bedtime |
|
Indication: Hypertension, Diabetic Nephropathy Age: Adult Condition: Initial (with diuretic) |
Dose: Oral - 1.25 mg Frequency: once daily at bedtime |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Safety and efficacy not established Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance 10-30 ml/min |
Dose: Dosage – Initially, 1.25 mg/day Frequency: once daily Note: Maximum: 5 mg/day |
|
Condition: Renal impairment: Creatinine Clearance 30-60 ml/min |
Dose: Dosage – Maintenance dose: 5 mg/day Frequency: once daily Note: Not necessary to adjust the initial dose. Maximum maintenance dose: 5 mg/day. |
Administration
- Can be taken with or without food
- Take at same time daily
Side Effect
- Cough (7-8%)
- Hypotension (2-11%)
- Headache (1-5%)
- Angina pectoris (3%)
- Dizziness (2-4%)
- Nausea (2%)
- Vomiting (2%)
- Postural hypotension (2%)
- Syncope (2%)
- Vertigo (2%)
- Abnormal kidney function (1%)
- Diarrhea (1%)
- Angioedema (0.3%)
- Severe hypotension and renal failure
- angioedema
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene), Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil)
|
May enhance hypotensive effect
|
|
NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
May increase risk of renal function deterioration
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Bilateral Renal Artery Stenosis
|
Dangerous kidney effects
|
|
Aortic Stenosis
|
Risk of low blood pressure
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store at 30° or below, protect from light. Keep out of the reach of children. Do not use later than the date of expiry. To be dispensed only on the prescription of a registered physician.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.