Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Chronic angina Age: Adult |
Dose: Oral – 500 mg by mouth initially Frequency: twice daily Note: may increase to 1,000 mg by mouth twice daily, if needed |
|
Indication: Chronic angina Age: Adult Condition: Mild Hepatic Impairment |
Dose: Oral Note: Dose titration needed |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: Not recommended |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal Impairment Mild to moderate (Creatinine Clearance 30-80 mL/minute) |
Dose: Dose titration needed Note: Dose titration needed for mild to moderate renal impairment |
|
Condition: Renal Impairment Severe (Creatinine Clearance less than 30 mL/minute) |
Dose: Contraindicated Note: Contraindicated in severe renal impairment |
Administration
- Can be taken with or without food
- Take at regular intervals
Side Effect
- Nausea (4-9%)
- Constipation (5-8%)
- Headache (3-6%)
- Palpitations
- Bradycardia
- Peripheral edema
- Prolonged QT interval
- Abdominal pain
- Dry mouth
- Dyspepsia
- Anorexia
- Vomiting
- Hematuria
- Dyspnea
- Tinnitus
- Vertigo
- Blurred vision
- Vasovagal syncope
- Confusional state
- Hematuria
- Hyperhidrosis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Diltiazem, Fluconazole, Erythromycin
|
Increased plasma levels of ranolazine
|
|
Verapamil, Ciclosporin
|
Increased plasma levels of ranolazine
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store Ranolazine tablets at 25°C with excursion permitted to 15° to 30°C. Protect from light and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.