Medicine Overview

Indication
Know Medicine, Follow Guideline

Adult Dose
Clinical InformationAdministration Information
Indication: Spasticity associated with multiple sclerosis and spinal cord injury
Age: Adult
Condition: Initial
Dose: Oral – 2 mg
Frequency: every 6-8 hours
Note: No more than 3 doses every 24 hours. Hepatic impairment: Avoid or use with extreme caution.
Indication: Spasticity associated with multiple sclerosis and spinal cord injury
Age: Adult
Condition: Maintenance
Dose: Oral – Increase by 2 to 4 mg
Note: Increase until satisfactory response is achieved with minimum 1-4 days between dose increments. Not to exceed 36 mg/day. Hepatic impairment: Avoid or use with extreme caution.

Child Dose
Clinical InformationAdministration Information
Age: Child
Dose: No approved pediatric dosage available
Note: Not recommended

Renal Dose
Clinical InformationAdministration Information
Condition: Renal impairment: Creatinine Clearance less than 25 ml/min
Dose: Dosage – 2 mg
Frequency: once daily
Note: Initially, 2 mg once daily, gradually increasing the dose before increasing the frequency of administration.
Administration
  • Take as directed
  • Follow prescribed schedule
Side Effect

Drug Interaction
Drug NameRisk Factors
Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil)
Potentiates hypotensive effect
Alcohol, CNS depressants
Increased CNS effects

Disease Interaction
Disease NameRisk Factors
Severe Hepatic Dysfunction
Can cause liver damage

Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a dry place below 30°C. Tizanidine must be kept out of the reach and sight of children.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.