Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Congestive Heart Failure (CHF)-associated edema Age: Adult |
Dose: Oral – 250-375 mg Frequency: once daily in the morning |
|
Indication: Seizure Age: Adult |
Dose: Oral – 8-30 mg/kg/day Frequency: once daily or divided every 12 hours |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Epilepsy Age: less than 12 years |
Dose: Tablet – Dosage not established Note: Safety and efficacy not established |
|
Indication: Epilepsy Age: greater than 12 years |
Dose: Tablet – 8-30 mg/kg/day Frequency: once daily or divided every 6-12 hours Note: by mouth (oral); not to exceed 30 mg/kg/day or 1 g/day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment Creatinine Clearance 10-50 mL/min |
Dose: dosage form not specified – dose not specified Frequency: administer no more frequently than every 12 hours |
|
Condition: Renal impairment Creatinine Clearance less than 10 mL/min |
Dose: dosage form not specified – dose not specified Note: Ineffective (avoid use) |
Administration
- Take with food to reduce stomach upset
- Take with a full glass of water
Side Effect
- Drowsiness
- paraesthesia
- ataxia
- dizziness
- thirst
- anorexia
- headache
- confusion
- malaise
- depression
- GI distress
- metabolic acidosis
- polyuria
- hyperuricaemia
- renal calculi
- nephrotoxicity
- hepatic dysfunction
- Rarely, skin reactions or blood dyscrasias
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
High-dose aspirin
|
May cause anorexia, tachypnoea, lethargy, metabolic acidosis, coma and death
|
|
Phenytoin
|
May increase serum levels, resulting in increased risk of osteomalacia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Sodium/Potassium Depletion
|
Can worsen electrolyte imbalance
|
|
Hepatic Insufficiency, Cirrhosis
|
Risk of liver complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.