Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oral Tuberculosis Age: Adult Condition: Initial Phase |
Dose: Tablet – 2 tablets Frequency: once daily Duration: 2 months Note: Isoniazid + Pyrazinamide + Rifampicin. Total Dosage Requirement: Rifampicin: 10 (8-12) mg/kg body mass/day. Isoniazid: 5 (4-6) mg/kg body mass/day. Pyrazinamide: 25 (20-30) mg/kg body mass/day. |
|
Indication: Oral Tuberculosis Age: Adult Condition: Initial Phase |
Dose: Tablet – 3 tablets Frequency: once daily Duration: 2 months Note: Isoniazid + Pyrazinamide + Rifampicin. Total Dosage Requirement: Rifampicin: 10 (8-12) mg/kg body mass/day. Isoniazid: 5 (4-6) mg/kg body mass/day. Pyrazinamide: 25 (20-30) mg/kg body mass/day. |
Child Dose
Details coming soon
Administration
- Take on empty stomach
- 1hr before/2hrs after food
Side Effect
- Unwanted effects which may occur during continuous daily or intermittent therapy Rifampicin Rifampicin may cause reddish discolouration of body fluids and occasionally other body secretions eg urine
- sputum
- lacrimal fluid
- faeces
- saliva and sweat
- It may permanently discolour soft contact lenses
- an asymptomatic increase in liver enzymes
- severe life-threatening hepatic reactions eg hepatic failure and acute fulminant hepatitis are uncommon (More than 0.1% andLess than 1%)
- In isolated cases (Less than 0.01%)
- a fatal outcome was observed
- Elevations of BUN and serum uric acid
- haemolysis
- haematuria
- interstitial nephritis
- renal insufficiency
- Nausea
- abdominal pains
- vomiting or diarrhoea
- pseudomembranous colitis
- Tiredness
- drowsiness
- headache
- dizziness
- ataxia
- mental confusion
- muscular weakness
- visual disturbances
- Haematological Changes Leucopenia
- eosinophilia
- thrombocytopenia and thrombocytopenic purpura
- Flushing
- itching with or without skin rash
- urticaria
- reddening of the eyes
- exudative conjunctivitis or generalised hypersensitivity reactions involving the skin eg exfoliative dermatitis
- Lyell's syndrome and pemphigoid reactions
- Disturbances in the menstrual cycle
- induction of crisis in Addison patients
- Unwanted effects chiefly occurring during intermittent therapy or upon resumption of treatment after temporary interruption
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Hormonal contraceptives, ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Antiemetics (Palonosetron, Ondansetron, Granisetron, Metoclopramide, Domperidone), Antineoplastics, Diuretics, Drugs for erectile dysfunction, Oral hypoglycaemics, NSAIDs (Ibuprofen, Naproxen, Diclofenac, Celecoxib, Meloxicam, Indomethacin, Piroxicam, Ketorolac)
|
Rifampicin may reduce effectivity
|
|
Atovaquone, Ketoconazole
|
Rifampicin may reduce serum levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Drug-induced hepatitis, Acute liver diseases, Peripheral neuritis
|
Risk of severe liver damage and nerve problems
|
|
Drug-induced hepatitis
|
High risk of severe liver damage
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Should be stored in cool and dry place
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.