Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Anxiety Age: Adult |
Dose: Tablet – 2-10 mg Frequency: by mouth every 6-12 hours Note: No more than 30 mg per 8 hours |
|
Indication: Anxiety Age: Adult |
Dose: Injection – 2-10 mg Frequency: intravenous or intramuscular every 6-12 hours Note: No more than 30 mg per 8 hours |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Sedative/Muscle Relaxant Age: less than 6 months |
Dose: Not recommended Note: Potentially toxic dose in patients less than 6 years: greater than 0.5 mg/kg |
|
Indication: Sedative/Muscle Relaxant Age: greater than 12 years |
Dose: Oral – 0.12-0.8 mg/kg/day Frequency: divided every 6-8 hours Note: by mouth (oral); Potentially toxic dose in patients less than 6 years: greater than 0.5 mg/kg |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult Condition: Renal impairment |
Dose: Oral – Data not available Note: No dose adjustment recommended unless administered for prolonged period; decrease dose in prolonged periods |
|
Condition: Renal impairment |
Dose: Rectal gel – Not studied Note: Use caution |
Administration
- Take on empty stomach
- Take 1 hour before or 2 hours after meals
Side Effect
- Atax (3%)
- Euphoria (3%
- rectal gel)
- Incoordination (3%
- rectal gel)
- Somnolence (More than 1%)
- Rash (3% rectal gel)
- Diarrhea (4%
- rectal gel)
- Common
- Hypotension
- Fatigue
- Muscle weakness
- Respiratory depression
- Urinary retention
- Depression
- Incontinence
- Blurred vision
- Dysarthria
- Headache
- Skin rash
- Changes in salivation
- Serious
- Neutropenia
- Jaundice
- Local effects Pain
- swelling
- thrombophlebitis
- carpal tunnel syndrome
- tissue necrosis
- Phlebitis if too rapid IV push
- Respiratory and CNS depression
- coma
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Amprenavir, Ritonavir
|
May significantly enhance CNS depressant effect
|
|
Anesthetics, Narcotic analgesics, Antidepressants (Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Venlafaxine, Duloxetine), Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole), Anxiolytics, Antiepileptics, Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), Antihypertensive (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, Propranolol, Metoprolol, Atenolol, Carvedilol, Bisoprolol, Nadolol, Amlodipine, Diltiazem, Verapamil, Nifedipine, Nicardipine, Hydrochlorothiazide, Chlorthalidone, Indapamide, Furosemide, Bumetanide, Torsemide, Spironolactone, Amiloride, Triamterene, Prazosin, Doxazosin, Terazosin, Clonidine, Methyldopa, Hydralazine, Minoxidil), Muscle Relaxants (Baclofen, Cyclobenzaprine, Tizanidine, Dantrolene) (e.g. tizanidine, baclofen), Nabilone
|
May enhance CNS depressant effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Myasthenia Gravis
|
Can worsen muscle weakness
|
|
CNS Depression
|
Can increase sedation
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool (below 25˚C temperature) and dry place protected from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.