Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Schizophrenia Age: Adults Condition: Starting Dose |
Dose: Oral – 12.5 mg Frequency: once daily or twice daily |
|
Indication: Schizophrenia Age: Adults Condition: Target Dose |
Dose: Oral – 300 mg to 450 mg Frequency: in divided doses |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Pediatric |
Dose: No approved pediatric dosage available Note: No approved pediatric dosage available |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Severe |
Dose: Not specified Note: Contraindicated |
Administration
- Can be taken with or without food
- Take at same times daily
Side Effect
- Sedation
- weight gain
- reversible neutropenia
- eosinophilia
- tachycardia
- orthostatic hypotension
- dizziness
- hypersalivation at night
- headache
- nausea
- vomiting
- constipation
- urinary incontinence and retention
- fatigue
- transient fever
- abnormalities of glucose homoeostasis and the onset of DM
- obsessive compulsive symptoms
- Anaemia
- thrombocytopenia
- thrombocythaemia
- extrapyramidal disorders including tardive dyskinesia
- circulatory collapse w/ cardiac and resp arrest
- HTN
- dysphagia
- parotid gland enlargement
- confusion
- delirium
- thromboembolism
- acute pancreatitis
- hepatitis and cholestatic jaundice
- Agranulocytosis
- myocarditis
- cardiomyopathy
- cardiac arrhythmias
- pericarditis/pericardial effusion
- neuroleptic malignant syndrome
- pulmonary embolism
- lower resp tract infection
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Bone marrow suppressants (e.g. carbamazepine, chloramphenicol), Sulfonamides, Pyrazolone analgesics, Penicillamine, Cytotoxic agents, Long-acting depot injections of Antipsychotics (Haloperidol, Risperidone, Quetiapine, Olanzapine, Clozapine, Aripiprazole)
|
Increased risk and/or severity of bone marrow suppression
|
|
Benzodiazepines (Diazepam, Alprazolam, Lorazepam, Clonazepam, Midazolam)
|
May increase risk of circulatory collapse leading to cardiac and/or respiratory arrest
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
History Of Bone Marrow Disorders Including Agranulocytosis
|
Can cause life-threatening blood disorders
|
|
Alcoholic Or Toxic Psychosis
|
Can worsen mental state
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Do not store above 30°C. Keep away from light and out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.