Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Benign gastric and duodenal ulceration Age: Adult |
Dose: Oral – 40 mg Frequency: once daily Duration: 4-8 weeks Note: at bedtime |
|
Indication: Benign gastric and duodenal ulceration Age: Adult |
Dose: Oral – 20 mg Frequency: twice daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Peptic Ulcer Age: 1-16 years |
Dose: Oral – 0.5 mg/kg Frequency: at bedtime Note: not to exceed 40 mg/day; by mouth (oral) |
|
Indication: Gastroesophageal Reflux Disease Age: less than 3 months |
Dose: Oral – 0.5 mg/kg Frequency: once daily Duration: for up to 8 weeks Note: by mouth (oral) |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment: Creatinine Clearance less than 50 ml/min |
Dose: dosage - Reduce the dose by half Note: Or increase dosing interval to 36-48 hours |
Administration
- Take with or without food
- Take regularly
Side Effect
- Headache (4.7%)
- Diarrhea (1.7%)
- Dizziness (1.3%)
- Constipation (1.2%)
- Fever
- asthenia
- fatigue
- Cardiovascular Arrhythmia
- AV block
- palpitation
- prolonged QT interval in patients with impaired renal function
- has been reported very rarely
- Gastrointestinal Cholestatic jaundice
- hepatitis
- liver enzyme abnormalities
- vomiting
- nausea
- abdominal discomfort
- anorexia
- dry mouth
- Hematologic Rare cases of agranulocytosis
- pancytopenia
- leukopenia
- thrombocytopenia
- Hypersensitivity Anaphylaxis
- angioedema
- orbital or facial edema
- urticaria
- rash
- conjunctival injection
- Musculoskeletal Rhabdomyolysis
- musculoskeletal pain including muscle cramps
- arthralgia
- hallucinations
- confusion
- agitation
- depression
- anxiety
- decreased libido
- paresthesia
- insomnia
- somnolence
- convulsions
- in patients with impaired renal function
- have been reported very rarely
- Respiratory Bronchospasm
- interstitial pneumonia
- Skin Toxic epidermal necrolysis/Stevens-Johnson syndrome (very rare)
- alopecia
- acne
- pruritus
- dry skin
- flushing
- Special senses Tinnitus
- taste disorder
- Rare cases of impotence and rare cases of gynecomastia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Antacids
|
Slightly decrease bioavailability
|
|
Ketoconazole, Itraconazole
|
May reduce serum concentration
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for general drug reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.