Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Adult |
Dose: Intravenous or Intramuscular – 1 g Frequency: every 8 to 12 hours Note: Usual recommended dosage. |
|
Indication: Bone and Joint Infections Age: Adult |
Dose: Intravenous – 2 g Frequency: every 12 hours |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Age: Child |
Dose: Intravenous, Intramuscular – 90–150 mg/kg/day Frequency: every 8 hours |
|
Age: Child Condition: serious Pseudomonas infection |
Dose: Intravenous – 200–300 mg/kg/day Frequency: every 8 hours Note: maximum 8–12 g/day |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Loading dose – 1 g Note: Maintenance doses based on Creatinine Clearance. May need to increase doses by 50% in severe infections. |
|
Age: Adult Condition: CrCl 31-50 ml/min |
Dose: Maintenance dose – 1 g Frequency: every 12 hours |
Administration
- For hospital use only
- Must be administered by professional
Side Effect
- Transient increases in transaminases (3-9%)
- Eosinophilia (Less than 7%)
- Diarrhea (Less than 2%)
- Immune hypersensitivity reaction (2%)
- Phlebitis (Less than 2%)
- Rash (maculopapular or erythematous) (2%)
- Thrombocytosis (2%)
- Injection site pain (1%)
- pain
- Agranulocytosis
- Angioedema
- Asterixis
- Coma
- Dizziness
- Encephalopathy
- Fever
- Hallucinations
- Increased serum concentrations of bilirubin
- Leukopenia
- Lymphocytosis
- Metallic taste
- Myoclonia
- Nausea or vomiting
- Neuromuscular excitability
- Neutropenia
- Paresthesia
- Photosensitivity
- Pruritus
- Seizures
- Thrombocytopenia
- Transient increases in blood urea nitrogen (BUN) or serum creatinineeatinine
- Urticaria
- Anaphylactic reactions
- nephrotoxicity
- pseudomembranous colitis
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Aminoglycosides
|
May increase nephrotoxicity
|
|
BCG, Typhoid vaccine, Na picosulfate
|
May diminish therapeutic effect
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
No specific contraindications listed
|
Monitor for allergic reactions
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store below 25°C, protected from light and moisture. Reconstituted solutions are stable for up to 24 h if stored between 2°-8°C.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.