Medicine Overview

Indication

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Adult Dose

Clinical InformationAdministration Information
Indication: Supraventricular and ventricular arrhythmias
Age: Adult
Dose: Oral - 80 mg/day
Frequency: once daily or in 2 divided doses
Note: Increased gradually every 2-3 days. Usual dose: 160-320 mg/day in 2 divided doses.
Indication: Life-threatening ventricular arrhythmias
Age: Adult
Dose: Oral - 80 mg
Frequency: twice daily
Note: Increased gradually every 3 days to 240-320 mg/day in divided doses if needed.

Child Dose

Clinical InformationAdministration Information
Indication: Ventricular arrhythmias, atrial fibrillation, or atrial flutter
Age: 2 years and older
Dose: By mouth – 1.2 mg/kg (initial); 2.4 mg/kg (maximum)
Frequency: Three times daily
Note: Maximum Dose: 7.2 mg/kg/day
Indication: Ventricular arrhythmias, atrial fibrillation, or atrial flutter
Age: Younger than 2 years
Dose: By mouth – 30 mg/m2 multiplied by an age-dependent factor
Frequency: Three times daily

Renal Dose

Clinical InformationAdministration Information
Condition: Renal impairment: Creatinine Clearance 30-60 ml/min
Dose: Renal Dose – Half the usual dose
Note: Dosage Recommendation
Condition: Renal impairment: Creatinine Clearance 10-30 ml/min
Dose: Renal Dose – Quarter the usual dose
Note: Dosage Recommendation
Administration
  • Take on empty stomach
  • Take 1-2 hours before meals
Side Effect

Drug Interaction

Drug NameRisk Factors
Digoxin
May increase risk of bradycardia
Diuretics (Chlorothiazide, Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone, Bumetanide, Ethacrynic acid, Furosemide, Torsemide, Amiloride, Eplerenone, Spironolactone, Triamterene)
May increase risk of arrhythmias

Disease Interaction

Disease NameRisk Factors
Bronchial Asthma/COPD
Can cause severe breathing difficulties
Sick Sinus Syndrome/Bradycardia
Can cause dangerous heart rhythm problems

Pregnancy

Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, protected from light.

Data Sources

Clinical & regulatory information on this page is compiled from the following government sources:

DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.